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Targeting, dosimetry, and radioimmunotherapy of B-cell lymphomas with iodine-131-labeled LL2 monoclonal antibody.
TLDR
An interesting observation in this study was the marked drop in circulating B lymphocytes after the administration of radioiodinated LL2 or anticarcinoembryonic antigen MAbs, suggesting that this is a nonspecific radiation effect and not necessarily related to the binding of MAb to normal B cells.
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Clinical evaluation of tumor targeting with a high‐affinity, anticarcinoembryonic‐antigen‐specific, murine monoclonal antibody, MN‐14
TLDR
This report summarizes the initial clinical experience with the new MoAb, a second generation, CEA‐specific murine monoclonal antibody, MN‐14 (IMMU‐14), that has a tenfold higher affinity.
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Lymphoma imaging with a new technetium-99m labelled antibody, LL2
TLDR
These initial results suggest that this new 99mTc-labelled antibody imaging kit should be further investigated for its potential role in the staging and follow-up of lymphoma patients.
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Phase I clinical evaluation of a new murine monoclonal antibody (mu‐9) against colon‐specific antigen‐p for targeting gastrointestinal carcinomas
TLDR
Clinical studies have shown that the murine monoclonal antibody Mu‐9 has excellent tumor‐targeting abilities, and clinical studies were initiated to evaluate its application in colorectal cancers.
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Radioimmunodetection of non‐small cell lung cancer using technetium‐99m‐anticarcinoembryonic antigen immu‐4 fab′ fragment
TLDR
The authors evaluated the ability of the technetium 99m‐anticarcino‐embryonic antigen IMMU‐4 Fab′ fragment to localize NSCLC in vivo, measured its pharmacokinetics, and estimated its radiation dose.
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Monoclonal antibody therapy of cancer.
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Uptake of 99mTc-phytate in osteosarcoma cases
During routine liver spleen scintigraphic studies using 99mTc-phytate in patients with proven osteosarcoma, an unusual uptake of this radiopharamaeutical at the primary site was observed. In all,…
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Comparison of technetium 99m-phytate and technetium 99m-sulphur colloid in primary bone tumours
TLDR
It is concluded that the unusual accumulation of 99mTc-phytate at the tumour site is not due to any generalized reticuloendothelial phenomenon and that the radiopharmaceutical itself is responsible for this.
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TUMOR TARGETING IN PATIENTS WITH A SECOND GENERATION, HIGH-AFFINITY, ANTI- CARCINOEMBRYONIC ANTIGEN (CEA) MURINE MONOCLONAL ANTIBODY
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TARGETING STUDIES IN NON-HODGKINʼS LYMPHOMA PATIENTS WITH A NEW Tc-99M-LABELED MONOCLONAL ANTIBODY IMAGING AGENT
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