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LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells DOI 10.1194/jlr.M100358-JLR200
TLDR
In CaCo-2 cells, LXR/RXR activation increases gene expression of ABCA1 and ABCG1 and the basolateral efflux of cholesterol, suggesting thatABCA1 plays an important role in intestinal HDL production and cholesterol absorption. Expand
Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport.
TLDR
In CaCo-2 cells, polyunsaturated fatty acids decrease gene and protein expression of SREBP-1 and FAS mRNA, probably through interference with LXR activity, and increased endogenous fatty acid synthesis does not promote triacylglycerol-rich lipoprotein secretion. Expand
Mitochondrial Rac1 GTPase Import and Electron Transfer from Cytochrome c Are Required for Pulmonary Fibrosis*
TLDR
This study shows that Rac1 is localized in the mitochondria of alveolar macrophages from asbestosis patients, and mitochondrial import requires the C-terminal cysteine of Rac1 (Cys-189), which is post-translationally modified by geranylgeranylation. Expand
Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis.
TLDR
It is demonstrated that Rac1 null mice are protected from asbestos-induced pulmonary fibrosis, as determined by histological and biochemical analysis and suggests that a simple intervention may be useful to prevent progression of the disease. Expand
Involucrin--structure and role in envelope assembly.
TLDR
Current findings make it possible to propose specific models regarding the role of involucrin and the mechanism of its crosslinking as an envelope precursor, and these models provide clearly testable hypotheses that are expected to provide additional insights into the mechanisms of cornified envelope assembly. Expand
Apolipoprotein B mRNA abundance is decreased by eicosapentaenoic acid in CaCo-2 cells. Effect on the synthesis and secretion of apolipoprotein B.
TLDR
In CaCo-2 cells, compared with the effects of oleic acid, eicosapentaenoic acid impairs triglyceride transport in part by inhibiting apo B synthesis and secretion. Expand
Caveolin is present in intestinal cells: role in cholesterol trafficking?
TLDR
The results suggest that caveolin is present in intestinal and CaCo-2 cells and is associated with detergent-resistant microdomains of cellular membranes and may play a role in cholesterol trafficking in intestinal cells. Expand
Rac1-mediated Mitochondrial H2O2 Generation Regulates MMP-9 Gene Expression in Macrophages via Inhibition of SP-1 and AP-1*
TLDR
Rac1 regulates MMP-9 transcription via mitochondrial H2O2 generation, providing a potential mechanism by which Rac1 null mice fail to develop pulmonary fibrosis. Expand
Mitochondrial Cu,Zn-Superoxide Dismutase Mediates Pulmonary Fibrosis by Augmenting H2O2 Generation*
TLDR
A novel mechanism for the pathogenesis of pulmonary fibrosis where the antioxidant enzyme Cu,Zn-SOD translocates to the mitochondrial IMS to increase H2O2 generation in alveolar macrophages is demonstrated. Expand
Accelerated Development of Pulmonary Fibrosis via Cu,Zn-superoxide Dismutase-induced Alternative Activation of Macrophages*
TLDR
It is demonstrated that Cu,Zn-SOD polarized macrophages to an M2 phenotype, and Cu,SOD-mediated H2O2 levels modulated M2 gene expression at the transcriptional level by redox regulation of a critical cysteine in STAT6. Expand
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