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RETRACTED: Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children
BACKGROUND We investigated a consecutive series of children with chronic enterocolitis and regressive developmental disorder. METHODS 12 children (mean age 6 years [range 3-10], 11 boys) were… Expand
Tumour necrosis factor alpha in stool as a marker of intestinal inflammation
Stool TNF alpha concentrations were significantly increased in children with active Crohn's disease and active ulcerative colitis and in patients with inactive disease, either as a result of surgery or treatment with steroids. Expand
Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease.
It is suggested that this degree of TNF alpha production probably contributes significantly to the pathogenesis of both Crohn's disease and ulcerative colitis, by impairing the integrity of epithelial and endothelial membranes, increasing inflammatory cell recruitment, and by prothrombotic effects on the vascular endothelium. Expand
Disruption of sulphated glycosaminoglycans in intestinal inflammation
- S. Murch, T. Macdonald, J. Walker-Smith, P. Lionetti, M. Levin, N. Klein
- Medicine, Biology
- The Lancet
- 20 March 1993
It is suggested that inflammatory disruption of vascular and connective tissue GAGs may be an important pathogenetic mechanism, contributing to the leakage of protein and fluid, thrombosis, and tissue remodelling seen in inflammatory bowel disease. Expand
High endothelin-1 immunoreactivity in Crohn's disease and ulcerative colitis
It is suggested that local endothelin production by inflammatory cells may contribute to vasculitis in chronic inflammatory bowel disease by inducing intestinal ischaemia through vasoconstriction. Expand
A pilot study of N‐acetyl glucosamine, a nutritional substrate for glycosaminoglycan synthesis, in paediatric chronic inflammatory bowel disease
- S. Salvatore, R. Heuschkel, +5 authors S. Murch
- Alimentary pharmacology & therapeutics
- 1 December 2000
The breakdown of glycosaminoglycans is an important consequence of inflammation at mucosal surfaces, and inhibition of metalloprotease activity may be effective in treating chronic inflammation.
Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease.
TNF-alpha secreting cells are increased in the mucosa of inflamed intestine, regardless of pathogenesis, and higher levels are seen in patients with IBD than in UC, probably reflecting the extensive T-cell activation in Crohn's disease. Expand
Indications for investigation of chronic gastrointestinal symptoms.
Simple routine blood tests may select children with chronic gastrointestinal symptoms who require endoscopic assessment and are thus an important aid in the prediction of endoscopic status. Expand
Serum concentrations of tumour necrosis factor in childhood chronic inflammatory bowel disease
Accepted for publication 10 September 1990 Abstract Serum tumour necrosis factor a (TNFa) concentrations were measured by enzyme linked immunoadsorbent assay in 31 normal children and during 65… Expand
Aetiology and pathogenesis of chronic inflammatory bowel disease.
The evidence for and against cell-wall deficient mycobacteria species, viral infection of vascular endothelium and luminal contents as potential mechanisms of chronic activation and the evidence for local production of cytokines, arachidonic acid metabolites and reactive oxygen and nitrogen radicals are discussed. Expand