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The Alzheimer's disease neuroimaging initiative.
With increasing life expectancy in developed countries, the incidence of Alzheimer's disease (AD) and its socioeconomic impact are growing. Increasing knowledge of the mechanisms of AD facilitatesExpand
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Ways toward an early diagnosis in Alzheimer’s disease: The Alzheimer’s Disease Neuroimaging Initiative (ADNI)
With the increasing life expectancy in developed countries, the incidence of Alzheimer's disease (AD) and thus its socioeconomic impact are growing. Increasing knowledge over the last years about theExpand
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Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T
Histological studies suggest that hippocampal subfields are differently affected by aging and Alzheimer’s disease (AD). The aims of this study were: (1) To test if hippocampal subfields can beExpand
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Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease
Histopathological studies and animal models suggest that hippocampal subfields may be differently affected by aging, Alzheimer's disease (AD), and other diseases. High‐resolution images at 4 TeslaExpand
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Selective effect of age, Apo e4, and Alzheimer's disease on hippocampal subfields
Histopathological studies and animal models suggest that different physiological and pathophysiological processes exert different subfield specific effects on the hippocampus. High‐resolution imagesExpand
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Nearly automatic segmentation of hippocampal subfields in in vivo focal T2-weighted MRI
tl;dr
We present and evaluate a new method for automatically labeling the subfields of the hippocampal formation in focal 0.5×2.0mm resolution T2-weighted magnetic resonance images that can be acquired in the routine clinical setting with under 5 min scan time. Expand
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Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder.
CONTEXT Most neuroimaging studies of posttraumatic stress disorder (PTSD) have focused on potential abnormalities in the whole hippocampus, but the subfields of this structure, which have distinctiveExpand
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Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: Towards a harmonized segmentation protocol
tl;dr
This paper characterizes, both qualitatively and quantitatively, the variability in the existing manual segmentation protocols for labeling hippocampal and parahippocampal substructures in MRI, with the goal of guiding subsequent work on developing a harmonized substructure segmentation protocol. Expand
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Selective effect of Apo e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4 T
tl;dr
Apo e4 exerts a regionally selective effect on hippocampal subfields in normal aging and AD. Expand
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Widespread neocortical abnormalities in temporal lobe epilepsy with and without mesial sclerosis
tl;dr
PURPOSE Extrafocal structural abnormalities have been consistently described in temporal lobe epilepsy (TLE) with mesial temporal lobe sclerosis. Expand
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