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Astrocytic Purinergic Signaling Coordinates Synaptic Networks
The results indicate that astrocytes are intricately linked in the regulation of synaptic strength and plasticity and provide a pathway for synaptic cross-talk.
GABAA-receptor-associated protein links GABAA receptors and the cytoskeleton
A new cellular protein, GABAA-receptor-associated protein (GABARAP), is identified, which can interact with the γ2 subunit of GAB AA receptors and suggest a mechanism for the targeting and clustering of GabAA receptors.
Antibodies to the GABAB receptor in limbic encephalitis with seizures: case series and characterisation of the antigen
GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition
This Review discusses recent progress in the understanding of the dynamic regulation of GABAAR composition, trafficking to and from the neuronal surface, and lateral movement of receptors between synaptic and extrasynaptic locations.
Direct Protein Kinase C-dependent Phosphorylation Regulates the Cell Surface Stability and Activity of the Potassium Chloride Cotransporter KCC2*
- H. Lee, Joshua A. Walker, Jeffery R. Williams, Richard J. Goodier, J. A. Payne, S. Moss
- BiologyJournal of Biological Chemistry
- 12 October 2007
The studies suggest that PKC-dependent phosphorylation of KCC2 may play a central role in modulating both the functional expression of this critical transporter in the brain and the strength of synaptic inhibition.
NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor mediated currents
Blocking dephosphorylation of Ser940 reduced the glutamate-induced downregulation of KCC2 and substantially improved the maintenance of hyperpolarizing GABAergic inhibition.
Activation of estrogen receptor-β regulates hippocampal synaptic plasticity and improves memory
In hippocampal slices, ERβ activation enhanced long-term potentiation, an effect that was absent in slices from ERβ knockout mice, and the data suggest that activation of ERβ can regulate hippocampal synaptic plasticity and improve hippocampus-dependent cognition.
Constitutive Endocytosis of GABAA Receptors by an Association with the Adaptin AP2 Complex Modulates Inhibitory Synaptic Currents in Hippocampal Neurons
- J. Kittler, P. Delmas, J. Jovanovic, D. Brown, T. Smart, S. Moss
- BiologyThe Journal of Neuroscience
- 1 November 2000
It is suggested that GABAA receptors cycle between the synaptic membrane and intracellular sites, and their association with AP2 followed by recruitment into clathrin-coated pits represents an important mechanism in the postsynaptic modulation of inhibitory synaptic transmission.
Gephyrin Regulates the Cell Surface Dynamics of Synaptic GABAA Receptors
It is demonstrated that synaptic GABAA receptors have lower levels of lateral mobility compared with their extrasynaptic counterparts, and a specific role for gephyrin is suggested in reducing the diffusion of GAB AA receptors, facilitating their accumulation at inhibitory synapses.