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Prospective identification of tumorigenic breast cancer cells
TLDR
The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies. Expand
Stem cells, cancer, and cancer stem cells
Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitorExpand
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
TLDR
This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues. Expand
Endothelial and perivascular cells maintain haematopoietic stem cells
TLDR
HSCs reside in a perivascular niche in which multiple cell types express factors that promote HSC maintenance, and were depleted from bone marrow when Scf was deleted from endothelial cells or leptin receptor (Lepr)-expressing periv vascular stromal cells. Expand
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
TLDR
The results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs, which are required for haematopoiesis to persist for the lifetime of the animal. Expand
Efficient tumour formation by single human melanoma cells
A fundamental question in cancer biology is whether cells with tumorigenic potential are common or rare within human cancers. Studies on diverse cancers, including melanoma, have indicated that onlyExpand
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
TLDR
It is shown that Bmi-1 is required for the self-renewal of stem cells in the peripheral and central nervous systems but not for their survival or differentiation but restricted neural progenitors from the gut and forebrain proliferate normally in the absence of B mi-1. Expand
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
TLDR
Mechanistic differences between normal stem cells and cancer stem cells can thus be targeted to depletecancer stem cells without damaging normalstem cells. Expand
Asymmetric and symmetric stem-cell divisions in development and cancer
TLDR
Sean Morrison argues that asymmetric division is not necessary for stem-cell identity but rather is a tool that stem cells can use to maintain appropriate numbers of progeny. Expand
Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches
TLDR
Assessment of the physiological sources of the chemokine CXCL12 for HSC and restricted progenitor maintenance shows that Cxcl12 was primarily expressed by perivascular stromal cells and, at lower levels, by endothelial cells, osteoblasts and some haematopoietic cells. Expand
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