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15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-1beta-induced IKK enzymatic activity and IkappaBalpha degradation in rat chondrocytes through a PPARgamma-independent pathway.
The results suggest that 15d-PGJ(2) exerts its anti-inflammatory effect in rat chondrocytes by a PPARgamma-independent mechanism, which can be conferred to a partial inhibition of IkappaBalpha degradation. Expand
15‐Deoxy‐Δ12,14‐prostaglandin J2 inhibits IL‐1β‐induced IKK enzymatic activity and IκBα degradation in rat chondrocytes through a PPARγ‐independent pathway
Peroxisome proliferator‐activated receptor γ (PPARγ) ligands have been shown to inhibit the effects of proinflammatory cytokines such as interleukin‐1β (IL‐1β). This cytokine plays a key role in… Expand
Identification and pharmacological characterization of platelet-activating factor and related 1-palmitoyl species in human inflammatory blistering diseases.
- J. Travers, R. Murphy, +7 authors D. Williams
- Chemistry, Medicine
- Prostaglandins & other lipid mediators
- 1 August 1998
The presence of 1-hexadecyl as well as the 1-acyl PAF analog 1-palmitoyl-2-acetyl glycerophosphocholine (PAPC) in inflammatory blister fluid samples suggest possible involvement of PAF and related species in inflammatory bullous diseases. Expand
Antiinflammatory activity of the platelet-activating factor receptor antagonist A-85783
- J. Travers, Y. Pei, S. Morin, A. Hood, J. Travers
- Biology, Medicine
- Archives of Dermatological Research
- 1 October 1998
It is demonstrated that epicutaneous A-85783 is an appropriate tool to study the role of the PAF receptor in cutaneous inflammation, and the possible clinical utility of this new class of antiinflammatory agents is suggested. Expand
Modulation of interleukin-1 receptor antagonist by peroxisome proliferator-activated receptor gamma agonists in rat synoviocytes is PPARgamma-independent
enzymatic activity and IjBa degradation in rat chondrocytes through a PPARc-independent pathway
Peroxisome proliferator-activated receptorc (PPARc) ligands have been shown to inhibit the effects of proinflammatory cytokines such as interleukin-1b (IL-1b). This cytokine plays a key role in… Expand