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Signal transduction in the onset of terminal keratinocyte differentiation induced by 1 alpha,25-dihydroxyvitamin D3: role of protein kinase C translocation.
TLDR
The findings imply that PKC is necessary but not sufficient for the onset of terminal differentiation by 1 alpha,25(OH)2D3, and also that another as yet unspecified signal generated specifically by the active vitamin D3 is required for keratinocyte differentiation. Expand
Defective formation of inositol 1,4,5-trisphosphate in bradykinin-stimulated fibroblasts from progressive systemic sclerotic patients.
TLDR
The findings suggest that bradykinin stimulates phosphoinositide hydrolysis by phospholipase C in human fibroblasts via IAP-insensitive pathway, and that PSS fibro Blasts appear to be defective in the pathway. Expand
Freeze-fracture cytochemical study of membrane systems in human epidermis using filipin as a probe for cholesterol.
TLDR
The results suggest that keratinocytes undergo a distinctive reduction in membrane deformability or in free-cholesterol content at the transition from living to dead cells, and display a heterogeneity in cholesterol distribution in human epidermal cell membranes. Expand
Purification and characterization of lysophospholipase-transacylase of pathogenic fungus Candida albicans.
TLDR
The results suggest that C. albicans lysophospholipase-transacylase is different from the corresponding mammalian enzymes in enzymatic properties. Expand
Involvement of phospholipase D in ganglioside GQ1b-induced biphasic diacylglycerol production in human keratinocytes.
TLDR
The results suggest that the phospholipase D pathway may contribute to the second phase of diacylglycerol formation, which might be involved in differentiation. Expand
Increased protein kinase C activity in fibroblast membranes from psoriatic patients.
TLDR
It is suggested that PKc is preferentially associated with the membrane in psoriatic fibroblasts and that such elevated PKc activity in membranes may play a role in the pathogenesis of this disease. Expand
Involvement of protein kinase C in bradykinin-induced intracellular calcium increase in primary cultured human keratinocytes.
TLDR
The results suggest that the BK-induced Ca2+ influx, which was shown as shoulder, may be negatively modulated by PKC in primary cultured human keratinocytes. Expand
The impairing effects of chaetochromin D on mitochondrial respiration and structure
TLDR
Chaetochromin D induced the same style of swelling as that induced by chaetochROMin A, being characterized by a very high rate and small amplitude of swelling. Expand
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