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Signal transduction in the onset of terminal keratinocyte differentiation induced by 1 alpha,25-dihydroxyvitamin D3: role of protein kinase C translocation.
The impairing effect of chaetochromin A and related mycotoxins on mitochondrial respiration
These three mycotoxins were revealed to inhibit the ATP synthesis in mitochondria by uncoupling oxidative phosphorylation and depressing state 3 respriration of mitochondria, which may be closely concerned in their cytotoxicity and in vivo toxicity to animals.
Defective formation of inositol 1,4,5-trisphosphate in bradykinin-stimulated fibroblasts from progressive systemic sclerotic patients.
Freeze-fracture cytochemical study of membrane systems in human epidermis using filipin as a probe for cholesterol.
- Y. Kitajima, T. Sekiya, S. Mori, Y. Nozawa, H. Yaoita
- BiologyThe Journal of investigative dermatology
- 1 February 1985
The results suggest that keratinocytes undergo a distinctive reduction in membrane deformability or in free-cholesterol content at the transition from living to dead cells, and display a heterogeneity in cholesterol distribution in human epidermal cell membranes.
Purification and characterization of lysophospholipase-transacylase of pathogenic fungus Candida albicans.
Involvement of phospholipase D in ganglioside GQ1b-induced biphasic diacylglycerol production in human keratinocytes.
- M. Seishima, Y. Aoyama, S. Mori, Y. Nozawa
- Biology, ChemistryThe Journal of investigative dermatology
- 1 May 1995
The results suggest that the phospholipase D pathway may contribute to the second phase of diacylglycerol formation, which might be involved in differentiation.
Increased protein kinase C activity in fibroblast membranes from psoriatic patients.
- S. Nagao, M. Seishima, S. Mori, Y. Nozawa
- Biology, MedicineThe Journal of investigative dermatology
- 1 March 1988
It is suggested that PKc is preferentially associated with the membrane in psoriatic fibroblasts and that such elevated PKc activity in membranes may play a role in the pathogenesis of this disease.
Involvement of protein kinase C in bradykinin-induced intracellular calcium increase in primary cultured human keratinocytes.
The impairing effects of chaetochromin D on mitochondrial respiration and structure
- S. Mori, K. Kawai, Y. Nozawa, K. Koyama, S. Natori
- Biology, ChemistryMycotoxin Research
- 1 September 1993
Chaetochromin D induced the same style of swelling as that induced by chaetochROMin A, being characterized by a very high rate and small amplitude of swelling.