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Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome
It is reasonable to speculate that elucidation of the key mediators in ARDS coupled with the discovery of specific inhibitors would make it possible to develop clinically effective anti‐inflammatory therapy. Expand
Involvement of ROS in BBB dysfunction
Observations suggest that ROS are key mediators of BBB breakdown and implicate antioxidants as potential neuroprotectants in conditions like stroke and traumatic brain injury (TBI). Expand
Chemokines in acute respiratory distress syndrome
- Padmam Puneet, S. Moochhala, M. Bhatia
- American journal of physiology. Lung cellular and…
- 1 January 2005
Recent evidence shows that activated leukocytes and chemokines play a key role in the pathogenesis of ARDS and the expanding number of antagonists of chemokine receptors for inflammatory disorders may hold promise for new medicines to combat ARDS. Expand
SphK1 Regulates Proinflammatory Responses Associated with Endotoxin and Polymicrobial Sepsis
It is found that the enzyme sphingosine kinase 1 (SphK1) is up-regulated in stimulated human phagocytes and in peritoneal phagocyte of patients with severe sepsis and suggest that inhibition of SphK1 is a potential therapy for septic shock. Expand
Role of hydrogen sulfide in acute pancreatitis and associated lung injury
- M. Bhatia, Fei Ling Wong, D. Fu, Hon Yen Lau, S. Moochhala, P. Moore
- FASEB journal : official publication of the…
- 1 April 2005
The presence of H2S synthesizing enzyme activity and CSE (as determined by mRNA signal) in the pancreas is reported and the effects of CSE blockade suggest an important proinflammatory role of H 2S in regulating the severity of pancreatitis and associated lung injury and raise the possibility that H2s may exert similar activity in other forms of inflammation. Expand
Hydrogen sulfide: from the smell of the past to the mediator of the future?
- P. Moore, M. Bhatia, S. Moochhala
- Chemistry, Medicine
- Trends in pharmacological sciences
- 1 December 2003
Recent work that suggests a role for H(2)S, and perhaps other gases, in the CNS and cardiovascular system is focused on. Expand
Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties.
- Shin-Yeu Ong, Jian Wu, S. Moochhala, M. Tan, Jia Lu
- Materials Science, Medicine
- 1 November 2008
This study demonstrated for the first time, the application of polyphosphate as a hemostatic adjuvant, and developed a new chitosan-based composite with potent he mostatic and antimicrobial properties. Expand
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study
The findings suggest that the beneficial effects of melatonin on abdominal pain in IBS patients with sleep disturbances are independent of its action on sleep disturbances or psychological profiles. Expand
Systemic inflammatory response following acute traumatic brain injury.
Important inflammatory mediators like interleukin (IL)-1 beta, IL-6 and tumour necrosis factor (TNF) alpha, are targeted in compensatory anti-inflammatory response syndrome (CARS) in an attempt to control the development of SIRS. Expand
Polymeric micelles anchored with TAT for delivery of antibiotics across the blood-brain barrier.
Polymeric micelles self-assembled from cholesterol-conjugated poly(ethylene glycol) (PEG) and anchored with transcriptional activator TAT peptide (TAT-PEG-b-Col) were fabricated for delivery of antibiotics across the blood-brain barrier (BBB) and proved to cross the BBB and enter the brain. Expand