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Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome
It is reasonable to speculate that elucidation of the key mediators in ARDS coupled with the discovery of specific inhibitors would make it possible to develop clinically effective anti‐inflammatory therapy.
Involvement of ROS in BBB dysfunction
Observations suggest that ROS are key mediators of BBB breakdown and implicate antioxidants as potential neuroprotectants in conditions like stroke and traumatic brain injury (TBI).
Chemokines in acute respiratory distress syndrome
- Padmam Puneet, S. Moochhala, M. Bhatia
- Medicine, BiologyAmerican Journal of Physiology - Lung cellular…
- 1 January 2005
Recent evidence shows that activated leukocytes and chemokines play a key role in the pathogenesis of ARDS and the expanding number of antagonists of chemokine receptors for inflammatory disorders may hold promise for new medicines to combat ARDS.
SphK1 Regulates Proinflammatory Responses Associated with Endotoxin and Polymicrobial Sepsis
It is found that the enzyme sphingosine kinase 1 (SphK1) is up-regulated in stimulated human phagocytes and in peritoneal phagocyte of patients with severe sepsis and suggest that inhibition of SphK1 is a potential therapy for septic shock.
Role of hydrogen sulfide in acute pancreatitis and associated lung injury
- M. Bhatia, F. Wong, D. Fu, Hon Yen Lau, S. Moochhala, P. Moore
- Medicine, BiologyThe FASEB Journal
- 1 April 2005
The presence of H2S synthesizing enzyme activity and CSE (as determined by mRNA signal) in the pancreas is reported and the effects of CSE blockade suggest an important proinflammatory role of H 2S in regulating the severity of pancreatitis and associated lung injury and raise the possibility that H2s may exert similar activity in other forms of inflammation.
Systemic inflammatory response following acute traumatic brain injury.
- Jia Lu, S. J. Goh, Priscilla Tng, Yiyu Deng, E. Ling, S. Moochhala
- Medicine, BiologyFrontiers in Bioscience
Important inflammatory mediators like interleukin (IL)-1 beta, IL-6 and tumour necrosis factor (TNF) alpha, are targeted in compensatory anti-inflammatory response syndrome (CARS) in an attempt to control the development of SIRS.
Hydrogen sulfide: from the smell of the past to the mediator of the future?
Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties.
Polymeric micelles anchored with TAT for delivery of antibiotics across the blood-brain barrier.
Polymeric micelles self-assembled from cholesterol-conjugated poly(ethylene glycol) (PEG) and anchored with transcriptional activator TAT peptide (TAT-PEG-b-Col) were fabricated for delivery of antibiotics across the blood-brain barrier (BBB) and proved to cross the BBB and enter the brain.
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study
The findings suggest that the beneficial effects of melatonin on abdominal pain in IBS patients with sleep disturbances are independent of its action on sleep disturbances or psychological profiles.