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An endothelial receptor for oxidized low-density lipoprotein
TLDR
The molecular cloning, using expression cloning strategy, of an Ox-LDL receptor from vascular endothelial cells is reported, which is a membrane protein that belongs structurally to the C-type lectin family, and is expressed in vivo in vascular endothelium and vascular-rich organs. Expand
TLR3 and TLR7 Are Targeted to the Same Intracellular Compartments by Distinct Regulatory Elements*♦
TLDR
These findings reveal that TLR3 and TLR7 contain unique targeting sequences, which differentially lead them to the same intracellular compartments and adjacent to phagosomes containing apoptotic cell particles, where these receptors may access their ligands for the induction of immune responses against viral infection. Expand
Cloning and Characterization of a Brain-specific Cationic Amino Acid Transporter*
TLDR
Results indicated a role of rCAT3 in the system y+ transporter activity in the nervous tissue and were specific for cationic amino acids as evidenced from the inhibition by L-arginine, L-lysine, and L-ornithine. Expand
Cholesterol Oxidation Switches the Internalization Pathway of Endothelin Receptor Type A from Caveolae to Clathrin-coated Pits in Chinese Hamster Ovary Cells*
TLDR
In Chinese hamster ovary cells, agonist-occupied ETA can be internalized either via caveolae or clathrin-coated pits; of the two, the former is the default pathway; and the oxidative state of cell surface cholesterol is one of the factors involved in the pathway selection. Expand
Endothelin receptor signaling: new insight into its regulatory mechanisms.
TLDR
This review focuses on the regulatory mechanisms of the ETR signaling with special attention to the components involved in Ca(2+) signaling and to GIPs in the signal transduction, modification, and degradation of ETRs. Expand
Reciprocal changes in endothelium‐derived hyperpolarizing factor‐ and nitric oxide‐system in the mesenteric artery of adult female rats following ovariectomy
TLDR
The results indicate that estrogen deficiency does not change the diameter of mesenteric artery: it reduces EDHF‐ mediated relaxation by decreasing gap junction, whereas it augments NO‐mediated relaxation via an increase in NO release. Expand
Different binding property of STIM1 and its novel splice variant STIM1L to Orai1, TRPC3, and TRPC6 channels.
TLDR
The results suggest that the higher binding capacity of STIM1L to SOCCs and ROCCs plays an important role in the regulation of Ca(2+) signaling such as the augmentation of SOCE via Orai1 and the inhibition of ROCE via TRPC3 and TRPC6. Expand
Pharmacological characterization of Ca2+ entry channels in endothelin‐1‐induced contraction of rat aorta using LOE 908 and SK&F 96365
TLDR
The results show that the contractions and increases in [Ca2+]i of rat aortic smooth muscles at lower concentrations of ET‐1 involve only one Ca2+ entry channel which is sensitive to SK&F 96365 but resistant to LOE 908 (SOCC) in addition to the former channel. Expand
Regulation of Inducible Nitric-oxide Synthase by the SPRY Domain- and SOCS Box-containing Proteins*
TLDR
iNOS levels are sophisticatedly regulated by SPSB proteins in activated macrophages to prevent overproduction of NO that could trigger detrimental effects, such as cytotoxicity. Expand
Endothelin-1-induced mitogenic responses of Chinese hamster ovary cells expressing human endothelinA: the role of a wortmannin-sensitive signaling pathway.
TLDR
The role of a Ca2+/PKC-independent, wortmannin-sensitive signaling pathway that linked ETA and MAPK cascade in the mitogenic signaling activated by ETA is suggested. Expand
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