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Predicting bioavailability of monoclonal antibodies after subcutaneous administration: Open innovation challenge.

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A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein.

The substrate specificity suggests that the substrate-binding pocket of BPHL has a hydrophobic acyl binding site which can accommodate the positively charged alpha-amino group, while having an alcohol leaving group binding site that can accommodate nucleoside analogues with a relatively generous spatial allowance.
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Prolidase, a potential enzyme target for melanoma: design of proline-containing dipeptide-like prodrugs.

Melphalan prodrugs such as prophalan-l that are cleavable by Prolidase offer the potential for enhanced selectivity by facilitating cytotoxic activity only in cells overexpressing prolidase.
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Chelating Resins and Their Applications in the Analysis of Trace Metal Ions

Simple, sensitive, and economical methods for the determination and solid phase extraction of metal ions using chelating resins in the past 25 years have been surveyed. Chelates immobilized or loaded…
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Design of Controlled Release PLGA Microspheres for Hydrophobic Fenretinide.

The objective was to deliver it as an injectable depot and improve the drug solubility and release behavior from poly(lactide-co-glycolide) (PLGA) microspheres by incorporating nonionic surfactants with fenretinide.
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Development of PLGA-Based Injectable Delivery Systems For Hydrophobic Fenretinide

Injectable carriers for fenretinide were successfully prepared, exhibiting excellent drug stability and based on the in vitro release properties of the different carriers, the preferred injection sites and in vivo release rates will be determined in future preclinical studies.
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Mechanistic analysis of triamcinolone acetonide release from PLGA microspheres as a function of varying in vitro release conditions

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Improving drug‐like properties of insulin and GLP‐1 via molecule design and formulation and improving diabetes management with device & drug delivery☆

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Proline prodrug of melphalan, prophalan-L, demonstrates high therapeutic index in a murine melanoma model.

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Recent Progress of Potentiating Immune Checkpoint Blockade with External Stimuli—an Industry Perspective

The recent advancement in external‐stimuli‐responsive nanoconstruct‐synergized immune checkpoint blockade is summarized, offering an industry perspective on the limitations of current academic innovations and discussing challenges in translation from a technical, manufacturing, and regulatory perspective.
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