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Contribution of KCNQ1 to the regulatory volume decrease in the human mammary epithelial cell line MCF-7.
Using the human mammary epithelial cell line MCF-7, we have investigated volume-activated changes in response to hyposmotic stress. Switching MCF-7 cells from an isosmotic to a hyposmotic solutionExpand
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Transient outward current carried by inwardly rectifying K+ channels in guinea pig ventricular myocytes dialyzed with low-K+ solution.
There have been periodic reports of nonclassic (4-aminopyridine insensitive) transient outward K+ current in guinea pig ventricular myocytes, with the most recent one describing a novel voltage-gatedExpand
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Tyrosine kinase and phosphatase regulation of slow delayed‐rectifier K+ current in guinea‐pig ventricular myocytes
The objective of this study was to investigate the involvement of tyrosine phosphorylation in the regulation of the cardiac slowly activating delayed‐rectifier K+ current (IKs) that is important forExpand
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Selective block of swelling-activated Cl- channels over cAMP-dependent Cl- channels in ventricular myocytes.
The objective of this study on guinea-pig and rabbit ventricular myocytes was to evaluate the sensitivities of swelling-activated Cl- current (ICl(swell)) and cAMP-dependent cystic fibrosisExpand
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CESE: Cell Electrophysiology Simulation Environment.
UNLABELLED Cell electrophysiology simulation environment (CESE) is an integrated environment for performing simulations with a variety of electrophysiological models that have Hodgkin-Huxley andExpand
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Osmotic modulation of slowly activating IKs in guinea-pig ventricular myocytes.
AIMS The aims of the study were to determine the effects of anisosmotic bathing solution on selected properties of I(Ks), the slowly activating delayed-rectifier K(+) current important forExpand
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Low-affinity block of cardiac K(+) currents by nifedipine.
Nifedipine inhibits a variety of K(+) currents with IC(50) between 4 and 40 microM. Among the more sensitive of these are two types (transient outward and ultrarapid hKv1.5) found in the heart. ToExpand
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Block of cardiac delayed‐rectifier and inward‐rectifier K+ currents by nisoldipine
The objective of this study was to determine the concentration‐dependent effects of nisoldipine, a dihydropyridine Ca2+ channel blocker, on K+ currents in guinea‐pig ventricular myocytes. Myocytes inExpand
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Regulation of wild-type and mutant KCNQ1/KCNE1 channels by tyrosine kinase
The objective of the study was to investigate the role of tyrosine phosphorylation in the regulation of KCNQ1/KCNE1 channels. Large whole-cell time- and voltage-dependent K+ currents were present inExpand
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Selective phenylalkylamine block of IKr over other K+ currents in guinea‐pig ventricular myocytes
Previous studies on verapamil and D600 have established that the Ca2+‐channel blockers also inhibit delayed‐rectifier K+ currents in cardiac tissues and myocytes. However, estimated IC50 values rangeExpand
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