• Publications
  • Influence
Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC.
  • S. Mirvish
  • Biology, Medicine
  • Cancer letters
  • 29 June 1995
The questions of whether and how N-nitroso compounds (NOC) may be inducing cancer in humans are discussed. The principal subjects covered include nitrite-derived alkylating agents that are not NOC,Expand
  • 774
  • 24
Formation of N-nitroso compounds: chemistry, kinetics, and in vivo occurrence.
  • S. Mirvish
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1 March 1975
  • 679
  • 17
The carcinogenic action and metabolism of urethan and N-hydroxyurethan.
  • S. Mirvish
  • Chemistry, Medicine
  • Advances in cancer research
  • 1968
Publisher Summary This chapter discusses the carcinogenic actions of urethane for several types of tumor, including lung adenomas, skin papillomas, malignant lymphomas, hepatomas, liver hemangiomas,Expand
  • 252
  • 6
Air-water and ether-water distribution of N-nitroso compounds: implications for laboratory safety, analytic methodology, and carcinogenicity for the rat esophagus, nose, and liver.
The air-water distribution ratio K1, ether-water distribution ratio K2, and solubility in water were measured for 17 nitrosamines, 3 nitrosamides, and 1 nitrosocyanamide. For K1, air was analysedExpand
  • 34
  • 6
Ascorbate-Nitrite Reaction: Possible Means of Blocking the Formation of Carcinogenic N-Nitroso Compounds
The formation of carcinogenic N-nitroso compounds by the chemical reaction between nitrous acid and oxytetracycline, morpholine, piperazine, N-methylaniline, methylurea, and (in some experiments)Expand
  • 478
  • 5
Duodenoesophageal reflux and the development of esophageal adenocarcinoma in rats.
BACKGROUND The carcinogenic effect of duodenoesophageal reflux, gastroesophageal reflux, and nitrosamines was studied in the rat esophagus. METHODS Twenty male Sprague-Dawley rats underwentExpand
  • 221
  • 5
Effects of vitamins C and E on N‐nitroso compound formation, carcinogenesis, and cancer
The properties of N‐nitroso compounds (NNC) and of vitamins C and E are briefly described. The author reviews the ability of vitamins C and E to inhibit NNC formation in chemical systems, inExpand
  • 212
  • 3
Study of the carcinogenicity of large doses of dimethylnitramine, N-nitroso-L-proline, and sodium nitrite administered in drinking water to rats.
Large doses of dimethylnitramine (DMNM), N-nitroso-L-proline (NPRO), and sodium nitrite were administered in the drinking water to MRC Wistar rats for at least 1 year, and the rats were maintainedExpand
  • 98
  • 3
Gastric juice protects against the development of esophageal adenocarcinoma in the rat.
OBJECTIVE The authors investigate the effects of gastric juice on tumorigenesis in a rat model of esophageal adenocarcinoma. SUMMARY BACKGROUND DATA In rats treated with the carcinogenExpand
  • 120
  • 3
Development of esophageal metaplasia and adenocarcinoma in a rat surgical model without the use of a carcinogen.
In order to establish an animal model for studying the cause and prevention of esophageal adenocarcinoma (EAC) and its frequent precursor, Barrett's esophagus (BE), factors affecting the pathogenicExpand
  • 162
  • 3