• Publications
  • Influence
Phosphatidylinositol 4-kinase is required for endosomal trafficking and degradation of the EGF receptor
The type II alpha isoform of phosphatidylinositol 4-kinase has recently been shown to function in the recruitment of adaptor protein-1 complexes to the trans-Golgi network. Here we show thatExpand
  • 120
  • 10
  • PDF
Cloning of a Human Type II Phosphatidylinositol 4-Kinase Reveals a Novel Lipid Kinase Family*
Phosphoinositide lipids regulate numerous cellular processes in all eukaryotes. The versatility of this phospholipid is provided by combinations of phosphorylation on the 3′, 4′, and 5′ positions ofExpand
  • 93
  • 8
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits
Accumulation of amyloid fibrils in the viscera and connective tissues causes systemic amyloidosis, which is responsible for about one in a thousand deaths in developed countries. Localized amyloidExpand
  • 277
  • 4
  • PDF
Oxysterol Binding Protein-dependent Activation of Sphingomyelin Synthesis in the Golgi Apparatus Requires Phosphatidylinositol 4-Kinase IIα
The study identifies a sterol- and oxysterol binding protein (OSBP)-regulated phosphatidylinositol 4-kinase that regulates ceramide transport protein (CERT) activity and sphingomyelin (SM) synthesis.Expand
  • 81
  • 4
  • PDF
Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIα at the trans-Golgi network
Type II phosphatidylinositol 4-kinase IIα (PI4KIIα) is the dominant phosphatidylinositol kinase activity measured in mammalian cells and has important functions in intracellular vesicularExpand
  • 52
  • 4
Lipid and Peptide Control of Phosphatidylinositol 4-Kinase IIα Activity on Golgi-endosomal Rafts*
The most abundant and widely expressed mammalian phosphoinositide kinase activity is contributed by phosphatidylinositol 4-kinase IIα (PI4KIIα). In this study we demonstrate that PI4KIIα is a novelExpand
  • 53
  • 3
The phosphatidylinositol 4-kinases: don't call it a comeback.
Phosphatidylinositol 4-phosphate (PtdIns4P) is a quantitatively minor membrane phospholipid which is the precursor of PtdIns(4,5)P (2) in the classical agonist-regulated phospholipase C signallingExpand
  • 33
  • 2
Detergent-free isolation and characterization of cholesterol-rich membrane domains from trans-Golgi network vesicles
Cholesterol is an abundant lipid of the trans-Golgi network (TGN) and of certain endosomal membranes where cholesterol-rich microdomains are important in the organization and compartmentalization ofExpand
  • 37
  • 2
  • PDF
The Friedreich's ataxia gene encodes a novel phosphatidylinositol–4–phosphate 5–kinase
The STM7 gene on chromosome 9 was recently ‘excluded‘ as a candidate for Friedreich's ataxia following the identification of an expanded intronic GAA triplet repeat in the adjacent gene, X25, inExpand
  • 71
  • 1