Acceleration of the Healing Process and Myocardial Regeneration May Be Important as a Mechanism of Improvement of Cardiac Function and Remodeling by Postinfarction Granulocyte Colony–Stimulating…
- S. Minatoguchi, G. Takemura, H. Fujiwara
- Biology, MedicineCirculation
- 1 June 2004
G accelerates absorption of necrotic tissues via increase of macrophages and reduces granulation and scar tissues via expression of MMPs, which suggests that G plays an important role for the beneficial effect of post-MI G-CSF treatment.
Reduction of inflammatory cytokine expression and oxidative damage by erythropoietin in chronic heart failure.
- Yiwen Li, G. Takemura, H. Fujiwara
- Medicine, BiologyCardiovascular Research
- 1 September 2006
Preventive Effect of Erythropoietin on Cardiac Dysfunction in Doxorubicin-Induced Cardiomyopathy
- Longhu Li, G. Takemura, H. Fujiwara
- Medicine, BiologyCirculation
- 31 January 2006
Erythropoietin protected hearts against doxorubicin-induced cardiomyocyte atrophy and degeneration, myocardial fibrosis, inflammatory cell infiltration, and downregulation of expression of GATA-4 and 3 sarcomeric proteins, myosin heavy chain, troponin I, and desmin.
Volumetric quantitative analysis of tissue characteristics of coronary plaques after statin therapy using three-dimensional integrated backscatter intravascular ultrasound.
- M. Kawasaki, K. Sano, H. Fujiwara
- MedicineJournal of the American College of Cardiology
- 21 June 2005
Resveratrol reverses remodeling in hearts with large, old myocardial infarctions through enhanced autophagy-activating AMP kinase pathway.
- H. Kanamori, G. Takemura, S. Minatoguchi
- Biology, ChemistryAmerican Journal of Pathology
- 1 March 2013
The role of autophagy emerging in postinfarction cardiac remodelling.
- H. Kanamori, G. Takemura, S. Minatoguchi
- Biology, MedicineCardiovascular Research
- 15 July 2011
Findings suggest that cardiomyocyte autophagy is an innate mechanism that protects against progression of postinfarction cardiac remodelling, implying that augmenting autophagosomes could be a therapeutic strategy.
Assessment of vulnerable plaques causing acute coronary syndrome using integrated backscatter intravascular ultrasound.
- K. Sano, M. Kawasaki, H. Fujiwara
- MedicineJournal of the American College of Cardiology
- 21 February 2006
Postinfarction gene therapy against transforming growth factor-beta signal modulates infarct tissue dynamics and attenuates left ventricular remodeling and heart failure.
- Hideshi Okada, G. Takemura, H. Fujiwara
- Medicine, BiologyCirculation
- 1 October 2004
Postinfarction Treatment With an Adenoviral Vector Expressing Hepatocyte Growth Factor Relieves Chronic Left Ventricular Remodeling and Dysfunction in Mice
- Yiwen Li, G. Takemura, H. Fujiwara
- Medicine, BiologyCirculation
- 20 May 2003
Postinfarction HGF gene therapy improved LV remodeling and dysfunction through hypertrophy of cardiomyocytes, infarct wall thickening, preservation of vessels, and antifibrosis.
Critical Roles for the Fas/Fas Ligand System in Postinfarction Ventricular Remodeling and Heart Failure
- Yiwen Li, G. Takemura, H. Fujiwara
- Biology, MedicineCirculation Research
- 17 September 2004
The treatment of mice with adenovirus encoding soluble Fas, a competitive inhibitor of Fas ligand, resulted in suppression of granulation tissue cell apoptosis and produced a thick, cell-rich infarct scar containing rich vessels and bundles of smooth muscle cells with a contractile phenotype at the chronic stage (4 weeks after MI).
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