• Publications
  • Influence
A production of amino acids under possible primitive earth conditions.
  • S. Miller
  • Chemistry, Medicine
    Science
  • 15 May 1953
TLDR
In this study, an apparatus was built to circulate CHI4, NH3, H2O, and H2 past an electric discharge, and the resulting mixture has been tested for amino acids by paper chromatography.
Organic compound synthesis on the primitive earth.
TLDR
The present status of the problem of the origin of life is discussed, mainly with respect to the early chemical history of, and the synthesis of organic compounds on, the primitive earth.
The stability of the RNA bases: implications for the origin of life.
  • M. Levy, S. Miller
  • Medicine, Biology
    Proceedings of the National Academy of Sciences…
  • 7 July 1998
TLDR
The half-lives for the decomposition of the nucleobases have been found to be short on the geologic time scale and it is concluded that a high-temperature origin of life may be possible, but it cannot involve adenine, uracil, guanine, or cytosine.
Impact melting of frozen oceans on the early Earth: Implications for the origin of life
  • J. Bada, C. Bigham, S. Miller
  • Environmental Science, Medicine
    Proceedings of the National Academy of Sciences…
  • 15 February 1994
TLDR
It is shown that bolide impacts between about 3.6 and 4.0 billion years ago could have episodically melted an ice-covered early ocean and could have been important for the initiation of abiotic reactions that gave rise to the first living organisms.
Which organic compounds could have occurred on the prebiotic earth?
  • S. Miller
  • Chemistry, Medicine
    Cold Spring Harbor symposia on quantitative…
  • 1987
Carbon Dioxide Clathrate in the Martian Ice Cap
TLDR
Measurements of the dissociation pressure of carbon dioxide hydrate show that this hydrate is stable relative to solid CO2 and water ice at temperatures above about 121�K, and it is likely to be present in the martian ice cap.
Peptide nucleic acids rather than RNA may have been the first genetic molecule.
TLDR
It is shown here that AEG is produced directly in electric discharge reactions from CH(4), N(2), NH(3), and H(2)O, and the possibility of polymerization of AEG reinforce the possibility that PNA may have been the first genetic material.
Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells
TLDR
Overexpression of Nek3 in Chinese hamster ovary transfectants potentiated cytoskeletal re-organization in response to PRL and analysis of breast tissue microarrays suggest that Nek3 contributes toPRL-mediated breast cancer motility through mechanisms involving Rac1 activation and paxillin phosphorylation.
Environmental and botanical controls on peatification - a comparative study of two New Zealand restiad bogs using Py-GC/MS, petrography and fungal analysis
Abstract This study shows that chemical properties of two restiad species, Empodisma minus and Sporadanthus traversii , may contribute to their success as peat-formers in a climate of the North
The case for an ancestral genetic system involving simple analogues of the nucleotides.
TLDR
It is proposed that RNA was preceded in the evolution of life by a polymer constructed from flexible, acyclic, probably prochiral nucleotide analogues that were synthesized readily on the primitive earth.
...
1
2
3
4
5
...