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Connexins, gap junctional intercellular communication and kinases
A number of kinases and signal transduction pathways are known to affect gap junctional intercellular communication and/or phosphorylation of connexins, but much less is known about protein kinase G, Ca2+‐calmodulin dependent protein Kinase, and casein kinase. Expand
Computational Methods for Mass Spectrometry Proteomics
Computational methods for mass spectrometry proteomics , Computational methods for mass spectrometry proteomics , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
The vertebrate connexin family
It is shown that the original connexin might be related to the ortholog groups of Cx36, 39.2, 43.4, 45 or 47, as judged from the recently defined connexins in tunicates. Expand
Stimulated phosphorylation of intracellular connexin43.
It is shown that Zymed 13-8300 can detect several phosphorylated species of connexin43 in Western blots after stimulation of two fibroblast cell systems with fresh growth medium, 12-O-tetradecanoyl phorbol-13-acetate, pervanadate, or permolybdate, and phosphorylation was induced by the agents. Expand
Ischemia Induces Closure of Gap Junctional Channels and Opening of Hemichannels in Heart-derived Cells and Tissue
- D. Johansen, V. Cruciani, R. Sundset, K. Ytrehus, S. Mikalsen
- Medicine, Chemistry
- Cellular Physiology and Biochemistry
- 1 August 2011
Connexin 43 is most likely responsible for both closure of gap junction channels and opening of hemichannels during simulated ischemia in neonatal rat heart myofibroblasts, and the infarct size becomes significantly reduced by preventing the opening of these channels during early ischemic injury in the heart. Expand
Increased gap junctional intercellular communication in Syrian hamster embryo cells treated with oxidative agents.
The results suggest that the cAMP/protein kinase A system may not be involved in the increase in GJIC caused by H2O2, although this cannot be completely ruled out. Expand
Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2.
- Kjersti Jørgensen, M. Skrede, V. Cruciani, S. Mikalsen, A. Slipicevic, V. A. Flørenes
- Biology, Medicine
- Biochemical and biophysical research…
- 1 April 2005
The results indicate that the protective effect of PMA on anchorage-independent survival of melanoma cells at least partly is mediated by MEK-independent activation of ERK1/2 and inactivation of downstream pro-apoptotic effector proteins. Expand
Pancreatic trypsin activates human promatrix metalloproteinase-2.
- R. I. Lindstad, I. Sylte, S. Mikalsen, P. Seglen, E. Berg, J. Winberg
- Chemistry, Medicine
- Journal of molecular biology
- 22 July 2005
The results suggest that the trypsin-activated MMP-2 possesses the catalytic and regulatory potential to be of significance in vivo. Expand
Phosphatases involved in modulation of gap junctional intercellular communication and dephosphorylation of connexin43 in hamster fibroblasts: 2B or not 2B?
Peptidyl-prolyl isomerase activity of cyclosporin/FK506/rapamycin-binding proteins may promote the dephosphorylation of connexin43 in cells. Expand
Evolutionary selection pressure and family relationships among connexin genes
The connexin gene family probably originated in the early evolution of chordates, and underwent major restructuring with regard to gene and subfamily structures (including the number of genes in each subfamily) during early vertebrate evolution. Expand