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Validated prediction model for the development of primary open-angle glaucoma in individuals with ocular hypertension.
TLDR
A quantitative calculator to estimate the 5-year risk of developing POAG, based on the pooled OHTS-EGPS predictive model, has high precision and will be useful for clinicians and patients in deciding the frequency of tests and examinations during follow-up and advisability of initiating preventive treatment. Expand
Risk factors for glaucoma onset and progression.
TLDR
The only modifiable factor associated with open-angle glaucoma that has been consistently identified is elevated baseline IOP, and future research needs to evaluate the importance of others modifiable factors such as IOP fluctuation or nutritional factors. Expand
Predictive factors for open-angle glaucoma among patients with ocular hypertension in the European Glaucoma Prevention Study.
TLDR
Baseline age, vertical C/D ratio, vertical D ratio asymmetry, and PSD were good predictors of the onset of OAG in the EGPS and support the need for a thorough evaluation of patients with ocular hypertension. Expand
Results of the European Glaucoma Prevention Study.
TLDR
The EGPS failed to detect a statistically significant difference between medical therapy and placebo in reducing the incidence of POAG among a large population of OHT patients at moderate risk for developing POAG, because placebo also significantly and consistently lowered IOP. Expand
Detection of glaucomatous visual field changes using the Moorfields regression analysis of the Heidelberg retina tomograph.
TLDR
In a broad clinical setting including normal subjects, patients with suspected POAG, and POAG patients, the HRT-MRA showed a high degree of diagnostic accuracy. Expand
Intraobserver and interobserver reproducibility in the evaluation of ultrasonic pachymetry measurements of central corneal thickness
TLDR
The measurement of CCT by means of ultrasonic pachymetry is highly reproducible, and the range of variability between two independent evaluations was ⩽±1% and ⩵± 2% respectively (95% confidence interval). Expand
Clinical ability of pattern electroretinograms and visual evoked potentials in detecting visual dysfunction in ocular hypertension and glaucoma.
TLDR
Combined PERG/VEP recordings identified a large percentage of ocular hypertension eyes with impairment of the innermost retinal layers, notwithstanding normal optic disc morphology and normal HFA. Expand
Retinal sensitivity and retinal nerve fiber layer thickness measured by optical coherence tomography in glaucoma.
TLDR
The results support the need to combine functional and structural tests in the detection of early glaucoma, and suggest the logarithmic equation may better explain the function/structure relationship between retinal sensitivity and OCT-measured RNFL thickness along a wide spectrum of glAUcoma continuum. Expand
Intercurrent factors associated with the development of open-angle glaucoma in the European glaucoma prevention study.
TLDR
The need for future investigations to better elucidate the role of systemic diuretics in the development of OAG is suggested, because IOP and disk hemorrhages have already been shown to be important intercurrent factors in the Ocular Hypertension Treatment Study (OHTS) and Early Manifest Glaucoma Trial (EMGT). Expand
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