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- Influence
Chronic Sustained Hypoxia Enhances Both Evoked EPSCs and Norepinephrine Inhibition of Glutamatergic Afferent Inputs in the Nucleus of the Solitary Tract
- Weirong Zhang, F. Carreño, J. Cunningham, S. Mifflin
- Chemistry, Medicine
- The Journal of Neuroscience
- 11 March 2009
The nucleus of the solitary tract (NTS) receives inputs from both arterial chemoreceptors and central noradrenergic neural structures activated during hypoxia. We investigated norepinephrine (NE)… Expand
Chronic sustained and intermittent hypoxia reduce function of ATP-sensitive potassium channels in nucleus of the solitary tract.
- Weirong Zhang, F. Carreño, J. Cunningham, S. Mifflin
- Biology, Medicine
- American journal of physiology. Regulatory…
- 1 November 2008
Activation of neuronal ATP-sensitive potassium (K(ATP)) channels is an important mechanism that protects neurons and conserves neural function during hypoxia. We investigated hypoxia (bath gassed… Expand
Chronic intermittent hypoxia alters NMDA and AMPA-evoked currents in NTS neurons receiving carotid body chemoreceptor inputs.
- P. M. de Paula, G. Tolstykh, S. Mifflin
- Biology, Medicine
- American journal of physiology. Regulatory…
- 1 June 2007
Chronic exposure to intermittent hypoxia (CIH) has been used in animals to mimic the arterial hypoxemia that accompanies sleep apnea. Humans with sleep apnea and animals exposed to CIH have elevated… Expand
Hypertension alters GABA receptor-mediated inhibition of neurons in the nucleus of the solitary tract.
- Lin Mei, J. Zhang, S. Mifflin
- Biology, Medicine
- American journal of physiology. Regulatory…
- 1 December 2003
Previous studies have demonstrated that microinjection of baclofen, a GABA(B) receptor agonist, into the nucleus of the solitary tract (NTS) results in an enhanced pressor response in hypertensive… Expand
Transient voltage-dependent potassium currents are reduced in NTS neurons isolated from renal wrap hypertensive rats.
- Sergei N Belugin, S. Mifflin
- Chemistry, Medicine
- Journal of neurophysiology
- 1 December 2005
Whole cell patch-clamp measurements were made in neurons enzymatically dispersed from the nucleus of the solitary tract (NTS) to determine if alterations occur in voltage-dependent potassium channels… Expand
Chronic Hypertension Enhances the Postsynaptic Effect of Baclofen in the Nucleus Tractus Solitarius
- Weirong Zhang, M. Herrera-Rosales, S. Mifflin
- Medicine
- Hypertension
- 1 March 2007
Microinjection of the inhibitory neurotransmitter &ggr;-aminobutyric acid B-subtype receptor agonist baclofen into the nucleus tractus solitarius increases arterial blood pressure and sympathetic… Expand
5-Hydroxytryptamine–Mediated Neurotransmission Modulates Spontaneous and Vagal-Evoked Glutamate Release in the Nucleus of the Solitary Tract Effect of Uptake Blockade
- P. Hosford, S. Mifflin, A. Ramage
- Chemistry, Medicine
- The Journal of Pharmacology and Experimental…
- 1 May 2014
The effect of blockade of either 5-hydroxytryptamine (5-HT)/serotonin transporter (SERT) with citalopram or the organic cation transporter 3 (OCT3)/plasma membrane monoamine transporter (PMAT) with… Expand
Plasticity of GABAergic mechanisms within the nucleus of the solitary tract in hypertension.
- Weirong Zhang, S. Mifflin
- Biology, Medicine
- Hypertension
- 1 February 2010
Adaptive changes have long been recognized to occur in the heart and vasculature in response to chronic hypertension. What might be less well-appreciated is the fact that chronically increased blood… Expand
Neurogenic mechanisms underlying the rapid onset of sympathetic responses to intermittent hypoxia.
- S. Mifflin, J. Cunningham, G. Toney
- Chemistry, Medicine
- Journal of applied physiology
- 15 December 2015
Sleep apnea (SA) leads to metabolic abnormalities and cardiovascular dysfunction. Rodent models of nocturnal intermittent hypoxia (IH) are used to mimic arterial hypoxemias that occur during SA. This… Expand
Chronic and intermittent hypoxia differentially regulate left ventricular inflammatory and extracellular matrix responses
- Trevi A. Ramirez, C. Jourdan-Le Saux, +4 authors M. Lindsey
- Biology, Medicine
- Hypertension Research
- 12 April 2012
We evaluated the left ventricle (LV) response to hypoxia by comparing male Sprague Dawley rats exposed for 7 days to normoxia (control; n=18), chronic sustained hypoxia (CSH; n=12) and chronic… Expand
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