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Human bradykinin B2 receptor sialylation and N-glycosylation participate with disulfide bonding in surface receptor dimerization.
TLDR
It is found that the human bradykinin B2 receptor undergoes similar glycosylation processes and similar cell surface organization in CHO-K1 and HEK 293 cells, used for stable and transient receptor expression, respectively. Expand
Long Term Stabilization of Expanding Aortic Aneurysms by a Short Course of Cyclosporine A through Transforming Growth Factor-Beta Induction
TLDR
It is demonstrated that pharmacological induction of TGF-beta1 by a short course of CsA administration represents a new approach to induce aneurysm stabilization by shifting the degradation/repair balance towards healing. Expand
New insight in aetiopathogenesis of aortic diseases.
TLDR
Future research needs to unravel distinct cellular and molecular mechanisms causing the clinical events, in particular, dissection, expansion of already formed aneurysms and rupture, and excludes causes related to infection, systemic inflammatory diseases and trauma. Expand
N-linked glycosylation of the human bradykinin B2 receptor is required for optimal cell-surface expression and coupling
TLDR
Results indicate that, for the human bradykinin B2 receptor, glycosylation is not required for optimal ligand binding, but plays an important role in cell-surface addressing and receptor function. Expand
Reestablishment of the Endothelial Lining by Endothelial Cell Therapy Stabilizes Experimental Abdominal Aortic Aneurysms
TLDR
The potential of restoring the endothelial lining to control AAA dynamics and ECs as an efficient therapy to stop AAA expansion is demonstrated. Expand
Chemokine (C-X-C Motif) Receptor 4 Blockade by AMD3100 Inhibits Experimental Abdominal Aortic Aneurysm Expansion Through Anti-Inflammatory Effects
TLDR
It is demonstrated that aortic SDF-1 overexpression is implicated in the recruitment of bone marrow–derived macrophage within the AAA wall and blockade of CXCR4 by AMD3100 decreases the infiltration of adventitial macrophages, inhibits AAA formation, and prevents aortIC wall destruction. Expand
New ascending aortic aneurysm model in rats reproduces main structural features of degenerative ascending thoracic aortic aneurysms in human beings.
TLDR
Elastase application on rat ascending aortic adventitia produced aneurysms, creating a reproducible model of Aortic wall remodeling, reproducing the main structural features of this disease in human beings. Expand
A Model of Hypoxia-Reoxygenation on Isolated Adult Mouse Cardiomyocytes
TLDR
An H/R model using adult cardiomyocytes freshly isolated from mice shows similar characteristics to the in vivo ischemia-reperfusion conditions and is used to investigate the cardioprotective effect of regular treadmill exercise. Expand
Palmitoylation of the human bradykinin B2 receptor influences ligand efficacy.
TLDR
The results suggest that palmitoylation is required for the stabilization of the receptor-ligand complex in an uncoupled conformation. Expand
Aortic length changes during abdominal aortic aneurysm formation, expansion and stabilisation in a rat model.
TLDR
Document aortic lengthening, its correlation to diameter, and determine how treatments that impact diameter also affect length, as a consequence of ECM injury driven by MMPs activated by the plasmin pathway. Expand
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