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Targeted inhibition of Ca2+ /calmodulin signaling exacerbates the dystrophic phenotype in mdx mouse muscle.
TLDR
The therapeutic potential of using targets of Ca(2+)/CaM-based signaling as a strategy for treating Duchenne muscular dystrophy (DMD) is illustrated and the concept that strategies aimed at promoting the slow oxidative myofiber program in muscle may be effective in altering the relentless progression of DMD is supported. Expand
The increased phosphorylation of ribosomal protein S6 in Arbacia punctulata is not a universal event in the activation of sea urchin eggs.
TLDR
The results suggest that different sea urchin species may rely on different mechanisms for the activation of protein synthesis. Expand
The Aquaporin Channel Repertoire of the Tardigrade Milnesium tardigradum
TLDR
Aquantin transcript expression in the anhydrobiotic context is analyzed and additional unorthodox aquaporins in various insect genomes are identified and a novel common conserved structural feature in these proteins is identified. Expand
Alteration of Ca2+ homeostasis of sea urchin embryos by retinoid CD 367, dual effect on egg cleavage and embryonic development.
TLDR
Since the authors were unable to detect nuclear receptors for CD 367 in sea urchin eggs and ovocytes, these effects probably are not related to interaction of the retinoid with members of the RAR family, but rather to its toxicity by the means of some unknown mechanisms. Expand