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Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines.
To investigate the cytotoxic potential of 412 extracts from Brazilian Cerrado plants used in traditional medicine belonging to 21 families against tumor cell lines in culture,Bioassay-guided fractionation of the last extract led to the isolation of glaucarubinone, which showed pronounced activity against the four cell lines studied. Expand
New neolignans and a lignan from Miliusa fragrans, and their anti-herpetic and cytotoxic activities
Seven new neolignans and a new lignan were isolated from the leaves and the stems of Miliusa fragrans, along with nine known polyphenolic compounds. Their structures were established through analysisExpand
The synthesis and angiotensin converting enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives.
A series of chalcones and pyrazoles was prepared to investigate their potential activity as Angiotensin I-Converting Enzyme (ACE) inhibitors and, among tested compounds, chalcone 7 exerted the highest activity. Expand
Marked antitumor activity of a new potent acronycine derivative in orthotopic models of human solid tumors.
In the two human lung cancer models, S 23906-1 increased the survival of the animals in a dose-dependent manner and induced treated versus control values of 162% (NCI-H460 and A549) and 193% (A549). Expand
Synthesis and cytotoxic activity of benzo[c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine.
In both series, compounds bearing oxygenated substituents at positions 8 and 9 exhibited cytotoxic properties towards L1210 murine leukemia cells, which may result from their capacities to intercalate into DNA. Expand
A new sphingolipid and furanocoumarins with antimicrobial activity from Ficus exasperata.
A new sphingolipid named Ficusamide, (2S,3S,4R,11E)-2-[(2',3'-dihydroxyhexacosanoylamino)]-11-octadecene-1,3,4-triol (1), along with three known furanocoumarins, showed wick activity and significant activity against Escherichia coli and Microsporum audouinii. Expand
One-step semisynthesis of oleacein and the determination as a 5-lipoxygenase inhibitor.
By exploiting oleuropein isolated from the plant leaf extract, an efficient procedure has been developed for a one-step semisynthesis of oleacein under Krapcho decarbomethoxylation conditions, facilitating the further development as a potential anti-inflammatory agent. Expand
New antitubulin derivatives in the combretastatin A4 series: synthesis and biological evaluation.
Two series of combretastatin A4 derivatives (acrylamide=carboxamide and carbamate) were synthesized in order to improve the water solubility and stabilize the cis-configuration of the double bond, and Potent inhibitions were observed on both tests in the carboxamide series. Expand
Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3',4',5'-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents.
The design and synthesis of several new disubstituted analogues of 1 are described, along with their biological evaluation as potential antivascular agents, and the identification of biologically potent CA-4 analogues 13 and 28 are identified. Expand
Benzo[b]acronycine derivatives: a novel class of antitumor agents.
A hypothesis of bioactivation of the antitumor alkaloid acronycine by transformation of the 1,2-double bond into the corresponding epoxide in vivo and the suggestion that acronyCine could interact with DNA, led to develop 1, 2-dihydroxy-1,1-2- dihydrobenzo[b]acronycines diesters as new anticancer drug candidates. Expand