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Genetic studies of body mass index yield new insights for obesity biology
TLDR
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility.
A versatile gene-based test for genome-wide association studies.
TLDR
This work derived a versatile gene-based test for genome-wide association studies (GWAS) that has the potential to identify novel associated genes; provide a basis for selecting SNPs for replication; and be directly used in network (pathway) approaches that require per-gene association test statistics.
Genome-wide association study identifies 74 loci associated with educational attainment
TLDR
Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
TLDR
A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent and significant loci and finds important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia.
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
TLDR
Three genetic loci are found to explain variation associated with educational achievement and provide promising candidate SNPs for follow-up work, and effect size estimates can anchor power analyses in social-science genetics.
Identification of seven loci affecting mean telomere length and their association with disease
TLDR
A genome-wide meta-analysis of 37,684 individuals with replication of selected variants in an additional 10,739 individuals supports a causal role of telomere-length variation in some age-related diseases.
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
We present an approximate conditional and joint association analysis that can use summary-level statistics from a meta-analysis of genome-wide association studies (GWAS) and estimated linkage
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
TLDR
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Assumption-Free Estimation of Heritability from Genome-Wide Identity-by-Descent Sharing between Full Siblings
TLDR
The application shows that it is feasible to estimate genetic variance solely from within-family segregation and provides an independent validation of previously untestable assumptions, and will allow partitioning of genetic variation into additive and non-additive components.
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
TLDR
A genome-wide association meta-analysis of 20,183 individuals diagnosed with ADHD and 35,191 controls identifies variants surpassing genome- wide significance in 12 independent loci and implicates neurodevelopmental pathways and conserved regions of the genome as being involved in underlying ADHD biology.
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