Author pages are created from data sourced from our academic publisher partnerships and public sources.
Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity.
Peptide:MHC II complexes derived from a fluorescent antigen were detected in vivo to identify the cells that present subcutaneously injected antigen to CD4 T cells. Skin-derived dendritic cells (DCs)… Expand
Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude.
Cell-mediated immunity stems from the proliferation of naive T lymphocytes expressing T cell antigen receptors (TCRs) specific for foreign peptides bound to host major histocompatibility complex… Expand
In vivo activation of antigen-specific CD4 T cells.
- M. Jenkins, Alexander Khoruts, +5 authors K. A. Pape
- Medicine, Biology
- Annual review of immunology
Physical detection of antigen-specific CD4 T cells has revealed features of the in vivo immune response that were not appreciated from in vitro studies. In vivo, antigen is initially presented to… Expand
Expression of T-bet by CD4 T Cells Is Essential for Resistance to Salmonella Infection1
- R. Ravindran, J. Foley, T. Stoklasek, L. Glimcher, S. McSorley
- Biology, Medicine
- The Journal of Immunology
- 1 October 2005
Despite the recognized role of the T-bet transcription factor in the differentiation of Th1 cells, T-bet-deficient mice can develop small numbers of IFN-γ-producing CD4 T cells. Although these are… Expand
CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches.
T cell activation by dendritic cells (DCs) is critical to the initiation of adaptive immune responses and protection against pathogens. Here, we demonstrate that a specialized DC subset in Peyer's… Expand
Tracking salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection.
- S. McSorley, Sarah Asch, M. Costalonga, R. Reinhardt, M. Jenkins
- Medicine, Biology
- 1 March 2002
A novel adoptive transfer system was used to track the fate of naive Salmonella-specific CD4 T cells in vivo. These cells showed signs of activation in the Peyer's patches as early as 3 hr after oral… Expand
Characterization of CD4+ T Cell Responses During Natural Infection with Salmonella typhimurium1
CD4+ T cells are important for resistance to infection with Salmonella typhimurium. However, the Ag specificity of this T cell response is unknown. Here, we demonstrate that a significant fraction of… Expand
Bacterial Flagellin Is an Effective Adjuvant for CD4+ T Cells In Vivo1
Flagellin is secreted by many enteric bacteria and, upon reaching the basolateral membrane of the intestinal epithelium, activates Toll-like receptor 5-mediated innate immune signaling pathways. We… Expand
Antibody Is Required for Protection against Virulent but Not Attenuated Salmonella entericaSerovar Typhimurium
ABSTRACT Resolution of infection with attenuated Salmonella is an active process that requires CD4+ T cells. Here, we demonstrate that costimulation via the surface molecule CD28, but not antibody… Expand
The Ets Transcription Factor Spi-B Is Essential for the Differentiation of Intestinal Microfold (M) Cells
Intestinal microfold cells (M cells) are an enigmatic lineage of intestinal epithelial cells that initiate mucosal immune responses through the uptake and transcytosis of luminal antigens. The… Expand