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Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness.
TLDR
Reciprocal changes involving subgenual cingulate and right prefrontal cortex occur with both transient and chronic changes in negative mood, suggesting that these regional interactions are obligatory and probably mediate the well-recognized relationships between mood and attention seen in both normal and pathological conditions. Expand
Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response
TLDR
Chronic treatment and clinical response to fluoxetine was associated with a reciprocal pattern of subcortical and limbic decreases and cortical increases, which suggests a process of adaptation in specific brain regions over time in response to sustained serotonin reuptake inhibition. Expand
The functional neuroanatomy of the placebo effect.
TLDR
The common pattern of cortical glucose metabolism increases and limbic-paralimbic metabolism decreases in placebo and fluoxetine responders suggests that facilitation of these changes may be necessary for depression remission, regardless of treatment modality. Expand
Mechanisms Underlying Age- and Performance-related Differences in Working Memory
TLDR
Neural efficiency and the capacity to allocate more resources to decision-making differed between high and low performers in both age groups, and demands appeared to have exceeded capacity in low performers, leading to a reduction of resources available to the decision- making process, which likely contributed to a decline in performance. Expand
Differential limbic–cortical correlates of sadness and anxiety in healthy subjects: implications for affective disorders
TLDR
These findings are interpreted within a model in which sadness and anxiety are represented by segregated corticolimbic pathways, where a major role is played by selective dorsal cortical deactivations during sadness, and ventral cortical deactivateations in anxiety. Expand
Unmasking disease-specific cerebral blood flow abnormalities: mood challenge in patients with remitted unipolar depression.
TLDR
Mood challenge in unipolar euthymic patients in full remission unmasks an apparent depression trait marker and suggests that disease-specific modifications of pathways mediating transient mood changes are present in un bipolar depression independent of clinical illness status. Expand
ERP correlates of item recognition memory: Effects of age and performance
TLDR
It is found that the FN400 and LPC were absent or attenuated in the older group relative to young adults, but that the LFE was actually increased, analogous to findings in the functional imaging literature. Expand
Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease
TLDR
Results of tau PET imaging serve as a key biomarker that links a specific type of molecular Alzheimer disease neuropathologic condition with clinically significant neurodegeneration, which will likely catalyze additional efforts to develop disease-modifying therapeutics. Expand
Age-Related Changes in the Thickness of Cortical Zones in Humans
TLDR
A sequential “developmental-sensory” model of aging is proposed, in which developmental factors influence cortical vulnerability relatively early in the aging process, whereas later—in more advanced stages of aging—factors specific to primary sensory and motor cortices confer vulnerability. Expand
To Ignore or Explore: Top-Down Modulation of Novelty Processing
TLDR
Evidence of the brain's ability to generate differential responses to novel events according to the circumstances under which they are encountered is provided, pointing to a greater degree of top--down modulation of the processing of novelty than has been previously emphasized. Expand
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