• Publications
  • Influence
A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat
TLDR
The present data indicate that a potent and selective antagonist of P 2X3 and P2X2/3 receptors effectively reduces both nerve injury and chronic inflammatory nociception, but P2x3 andP2X 2/3 receptor activation may not be a major mediator of acute, acute inflammatory, or visceral pain. Expand
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
TLDR
A-803467 is found, a sodium channel blocker that potently blocks tetrodotoxin-resistant currents and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons and produces significant antinociception in animal models of neuropathic and inflammatory pain. Expand
P2X7-related modulation of pathological nociception in rats
TLDR
ATP, acting through the P2X7 receptor, exerts a wide-ranging influence on spinal neuronal activity following a chronic injury and is likely mediated through immuno-neural interactions that affect the release of endogenous cytokines. Expand
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
TLDR
A potent, selective, and bioavailable antagonist that attenuates pathological pain without altering noxious cold sensation or body temperature regulation is used to suggest that the selective TRPA1 blockade may present a viable strategy for alleviating pain without untoward side effects. Expand
Painful Purinergic Receptors
TLDR
Some of the recent advances to identify selective P2 receptor ligands, which has enhanced the investigation of ATP-related modulation of pain sensitivity, are highlighted. Expand
Effects of A‐317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration
TLDR
Intrathecal administration of A‐317491 appears to be more effective than intraplantar administration to reduce tactile allodynia following peripheral nerve injury and data indicate that both spinal and peripheral P2X3/P2X2/3 receptors have significant contributions to nociception in several animal models of nerve or tissue injury. Expand
Circuitry underlying antiopioid actions of cholecystokinin within the rostral ventromedial medulla.
TLDR
CCK acting within the RVM attenuates the analgesic effect of systemically administered morphine by preventing activation of the putative pain inhibiting output neurons of the RVB, the OFF cells, which differs from another antiopioid peptide, orphanin FQ/nociceptin, which interferes with opioid analgesia by potently suppressing all OFF-cell firing. Expand
Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM.
TLDR
Results suggest that supraspinal VR1 receptors in the dPAG contribute to descending modulation of nociception. Expand
Circuitry underlying antiopioid actions of orphanin FQ in the rostral ventromedial medulla.
TLDR
It is demonstrated that, at least within the medulla, OFQ can exert a functional "antiopioid" effect by suppressing firing of this cell class, as activation of -cells can account for the antinociceptive action of opioids within the RVM. Expand
TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats
TLDR
Blockade of TRPA1 receptors disrupts transmission of high-intensity mechanical stimulation to the spinal cord in both uninjured and injured rats indicating that TRPA 1 receptors have an important role in noxious mechanosensation in both normal and pathological conditions. Expand
...
1
2
3
4
5
...