• Publications
  • Influence
Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
The precise role played by HIV-specific cytotoxic T lymphocytes (CTL) in HIV infection remains controversial. Despite strong CTL responses being generated during the asymptomatic phase, the virusExpand
  • 1,212
  • 61
The Intestinal T Cell Response to α-Gliadin in Adult Celiac Disease Is Focused on a Single Deamidated Glutamine Targeted by Tissue Transglutaminase
The great majority of patients that are intolerant of wheat gluten protein due to celiac disease (CD) are human histocompatibility leukocyte antigen (HLA)-DQ2+, and the remaining few normally expressExpand
  • 614
  • 12
  • PDF
Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues.
BACKGROUND & AIMS Celiac disease is a gluten-induced enteropathy that shows a strong association with HLA-DQ2 and -DQ8. Gluten-specific T cells, invariably restricted by DQ2 or DQ8, can be isolatedExpand
  • 318
  • 11
Unique comaximal factorization
  • 33
  • 7
Molecular cloning of orangutan and gibbon MHC class I cDNA. The HLA-A and -B loci diverged over 30 million years ago.
To investigate whether the classical HLA MHC class I loci have been preserved during evolution of the primates, we have cloned, sequenced, and expressed eight MHC class I cDNA from orangutan andExpand
  • 62
  • 5
Autoantibodies in coeliac disease: tissue transglutaminase—guilt by association?
Endomysial antibodies are a hallmark of coeliac disease. The existence of autoantibodies whose titres fluctuate with ingestion of gliadin is enigmatic. Gliadin seems to drive this antibody secretionExpand
  • 283
  • 4
  • PDF
Production of a panel of recombinant gliadins for the characterisation of T cell reactivity in coeliac disease
BACKGROUND/AIMS Coeliac disease is a chronic intestinal disorder most probably caused by an abnormal immune reaction to wheat gliadin. The identification of the HLA-DQ2 and HLA-DQ8 as the moleculesExpand
  • 80
  • 4
  • PDF
The MHC E locus in macaques is polymorphic and is conserved between macaques and humans
Although the functions of the molecules encoded by the classical MHC class I loci are well defined, no function has been ascribed to the molecules encoded by the non-classical MHC class I loci. ToExpand
  • 45
  • 4
Asymptotic Prime Divisors
A*(I) and B*(I).- A*(I) - B*(I).- ?*(I).- A characterization of ?*(I).- Asymptotic sequences.- Asymptotic sequences over ideals.- Asymptotic grade.- When A* = ?*.- Conforming relations.- IdealExpand
  • 160
  • 4
T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase
Celiac disease is an HLA‐DQ2‐associated disorder characterized by intestinal T cell responses to ingested wheat gliadins. Initial studies used gliadin that had been subjected to non‐enzymaticExpand
  • 179
  • 3