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Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation.
It is suggested that Otx2 expression in endomesoderm and ectoderm is required for anterior neuroectoderm specification, and in gastrulating heterozygous embryos, a post-transcriptional repression acts on lacZ transcripts in the ectodermal layer, but not in the external layer, suggesting that different post- transcriptional mechanisms control Otx1 expression in both layers. Expand
Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo.
A model whereby Otx2 functions in the anterior visceral endoderm to influence the ability of the adjacent epiblast cells to differentiate into anterior neurectoderm, indirectly, by preventing them from coming under the influence of posterior signals that regulate primitive streak formation is supported. Expand
Organisation of the lamprey (Lampetra fluviatilis) embryonic brain: insights from LIM-homeodomain, Pax and hedgehog genes.
The findings highlight a neuromeric organisation of the embryonic agnathan forebrain and point to the possible origin of this organisation, which is thus a truly vertebrate character, and suggest that Hh/Shh midline signalling might act as a driving force for forebrain evolution. Expand
Epilepsy and brain abnormalities in mice lacking the Otx1 gene
The findings indicate that the Otx1 gene product is required for proper brain functions, as indicated by spontaneous epileptic behaviour and multiple abnormalities affecting mainly the telencephalic temporal and perirhinal areas. Expand
Structural evolution of Otx genes in craniates.
- A. Germot, G. Lecointre, J. Plouhinec, C. Le Mentec, F. Girardot, S. Mazan
- Medicine, Biology
- Molecular biology and evolution
- 1 September 2001
The hypothesis that the Otx multigene families characterized in craniates all derive from duplications of a single ancestral gene which occurred after the splitting of cephalochordates but prior to the gnathostome radiation is supported. Expand
Pax6 expression patterns in Lampetra fluviatilis and Scyliorhinus canicula embryos suggest highly conserved roles in the early regionalization of the vertebrate brain
expression patterns of the Pax6 gene in the dogfish Scyliorhinus canicula and the lamprey Lampetra fluviatilis during neurulation and at the beginning of organogenesis suggest that the roles played by Pax6 in early brain regionalization have been highly conserved during vertebrate evolution. Expand
Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history
- L. Castro, O. Gonçalves, S. Mazan, B. Tay, B. Venkatesh, Jonathan M. Wilson
- Biology, Medicine
- Proceedings of the Royal Society B: Biological…
- 22 January 2014
It is established that the stomach loss correlates with the persistent and complete absence of the gastric function gene kit—H+/K+-ATPase (Atp4A and Atp4B) and pepsinogens (Pga, Pgc, Cym)—in the analysed species. Expand
Neurodevelopment Genes in Lampreys Reveal Trends for Forebrain Evolution in Craniates
Systematic expression patterns comparisons with model organisms highlight conservations likely to reflect shared features present in the vertebrate ancestors and point to changes in signaling systems which may have been crucial in the evolution of forebrain anatomy at the origin of vertebrates. Expand
Phylogenomic analysis and expression patterns of large Maf genes in Xenopus tropicalis provide new insights into the functional evolution of the gene family in osteichthyans
- M. Coolen, K. Sii-Felice, +6 authors J. Plouhinec
- Biology, Medicine
- Development Genes and Evolution
- 10 March 2005
An exhaustive characterization of the large Maf family of basic leucine zipper transcription factors in vertebrates using the genome data available, and studied the embryonic expression patterns of the four paralogous genes thus identified in Xenopus tropicalis, highlights the importance of exhaustive characterizations of gene families for comparative analyses of the genetic mechanisms. Expand
Pattern and polarity in the development and evolution of the gnathostome jaw: both conservation and heterotopy in the branchial arches of the shark, Scyliorhinus canicula.
- C. Compagnucci, M. Debiais-Thibaud, +9 authors M. Depew
- Biology, Medicine
- Developmental biology
- 15 May 2013
Evidence of heterotopic and heterochronic shifts in gene expression, relative to amniotes, in the jaw primordia of S. canicula embryos is investigated, establishing a baseline molecular baüplan for branchial arch-derived jaw development and validating the utility of the 'Hinge and Caps' model in comparative studies of jaws development and evolution. Expand