• Publications
  • Influence
Pathways of clathrin-independent endocytosis
  • S. Mayor, R. Pagano
  • Medicine, Biology
  • Nature Reviews Molecular Cell Biology
  • 1 August 2007
There are numerous ways that endocytic cargo molecules may be internalized from the surface of eukaryotic cells. In addition to the classical clathrin-dependent mechanism of endocytosis, severalExpand
  • 1,282
  • 83
  • PDF
GPI-anchored proteins are delivered to recycling endosomes via a distinct cdc42-regulated, clathrin-independent pinocytic pathway.
Endocytosis of cell-surface proteins via specific pathways is critical for their function. We show that multiple glycosylphosphatidylinositol-anchored proteins (GPI-APs) are endocytosed to theExpand
  • 622
  • 55
  • PDF
Nanoscale Organization of Multiple GPI-Anchored Proteins in Living Cell Membranes
Cholesterol and sphingolipid-enriched "rafts" have long been proposed as platforms for the sorting of specific membrane components including glycosyl-phosphatidylinositol-anchored proteins (GPI-APs),Expand
  • 824
  • 38
  • PDF
Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles
Using quantitative light microscopy and a modified immunoelectron microscopic technique, we have characterized the entry pathway of the cholera toxin binding subunit (CTB) in primary embryonicExpand
  • 405
  • 30
  • PDF
GPI-anchored proteins are organized in submicron domains at the cell surface
Lateral heterogeneities in the classical fluid-mosaic model of cell membranes are now envisaged as domains or ‘rafts’ that are enriched in (glyco)sphingolipids, cholesterol, specific membraneExpand
  • 1,150
  • 28
Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking.
Glycosyl-phosphatidylinositol (GPI)-anchored proteins have been reported to reside in clusters collected over small membrane invaginations called caveolae. The detection of different GPI-anchoredExpand
  • 497
  • 24
Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process
A central question in the endocytic process concerns the mechanism for sorting of recycling components (such as transferrin or low density lipoprotein receptors) from lysosomally directed components;Expand
  • 481
  • 22
  • PDF
Sorting GPI-anchored proteins
The study of glycosylphosphatidylinositol-anchored-protein sorting has led to some surprising new findings and concepts. Evidence is accumulating that, during their delivery to the surface, differentExpand
  • 413
  • 20
ARF1 is directly involved in dynamin-independent endocytosis
Endocytosis of glycosylphosphatidyl inositol (GPI)-anchored proteins (GPI-APs) and the fluid phase takes place primarily through a dynamin- and clathrin-independent, Cdc42-regulated pinocyticExpand
  • 192
  • 18
  • PDF
Clathrin-independent pathways of endocytosis.
There are many pathways of endocytosis at the cell surface that apparently operate at the same time. With the advent of new molecular genetic and imaging tools, an understanding of the different waysExpand
  • 291
  • 17
  • PDF