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Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp.
- D. Laurent, V. Jullian, +11 authors M. Sauvain
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 July 2006
As part of our search for new antimalarial drugs, we have screened for inhibitors of Pfnek-1, a protein kinase of Plasmodium falciparum, in south Pacific marine sponges. On the basis of a preliminary… Expand
Validation of use of a traditional antimalarial remedy from French Guiana, Zanthoxylum rhoifolium Lam.
- V. Jullian, G. Bourdy, S. Georges, S. Maurel, M. Sauvain
- Journal of ethnopharmacology
- 19 July 2006
Zanthoxylum rhoifolium bark (Rutaceae) is a medicinal plant, traditionally used in French Guiana to treat and prevent malaria. Bioassay-guided extractions of Zanthoxylum rhoifolium bark have shown… Expand
Antiplasmodial Activities of Homogentisic Acid Derivative Protein Kinase Inhibitors Isolated from a Vanuatu Marine Sponge Pseudoceratina sp.
As part of our search for new antimalarial drugs in South Pacific marine sponges, we have looked for inhibitors of Pfnek-1, a specific protein kinase of Plasmodium falciparum. On the basis of… Expand
Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives
Pterocarpanquinones 8a-c, previously synthesized in our laboratory, and an homologous series of derivatives, compounds 9a-c prepared in this work, were evaluated on breast cancer cells (MCF-7) and on… Expand
Blood schizontocidal activity of methylene blue in combination with antimalarials against Plasmodium falciparum.
Methylene blue (MB) is the oldest synthetic antimalarial. It is not used anymore as antimalarial but should be reconsidered. For this purpose we have measured its impact on both chloroquine sensitive… Expand
A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds.
- G. Garavito, M. Monje, S. Maurel, A. Valentin, F. Nepveu, E. Deharo
- Biology, Medicine
- Experimental parasitology
- 1 July 2007
Intraerythrocytic Plasmodium produces large amounts of toxic heme during the digestion of hemoglobin, a parasite specific pathway. Heme is then partially biocristallized into hemozoin and mostly… Expand
Daucane sesquiterpenes from Ferula hermonis.
- Amélie Lhuillier, N. Fabre, +5 authors C. Moulis
- Chemistry, Medicine
- Journal of natural products
- 3 March 2005
The dried roots of Ferula hermonis yielded three new daucanes, (1R,4R)-4-hydroxydauca-7-ene-6-one (1), (1R,4R)-4-hydroxydauca-7-ene-6,9-dione (2), and… Expand
Synthesis and antimalarial activity of new 3-arylquinoxaline-2-carbonitrile derivatives.
New series of 3-arylquinoxaline-carbonitrile derivatives have been synthesized from various 5-substituted or 5,6-disubstituted benzofuroxanes and tested for their in vitro and in vivo activity… Expand
Antiplasmodial structure-activity relationship of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide derivatives.
Derivatives of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide (4b-g, 5b-g, 6a-g) were synthesized and evaluated for their capacity to inhibit the growth of chloroquine-resistant… Expand
Antiplasmodial activity of 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives
The in vitro antiplasmodial activity of some 3-trifluoromethyl-2-carbonylquinoxaline di-N-oxide derivatives is reported. The evaluation was performed on cultures of FcB1 strain… Expand