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Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair
Fanconi anemia (FA) is a developmental and cancer-predisposition syndrome caused by mutations in genes controlling DNA interstrand crosslink repair. Several FA proteins form a ubiquitin ligase thatExpand
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Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+ exchanger.
The Na(+)-Ca2+ exchanger is an important regulator of cellular Ca2+ levels, and one isoform of this transporter, NCX1, has been cloned previously (Nicoll, D.A., Longoni, S., and Philipson, K.D.Expand
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Mutation of Amino Acid Residues in the Putative Transmembrane Segments of the Cardiac Sarcolemmal Na+-Ca2+ Exchanger*
We have examined the role of conserved regions and acidic or basic residues located in the putative transmembrane segments of the cardiac sarcolemmal Na+-Ca2+ exchanger by site-directed mutagenesis.Expand
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4F2 (CD98) Heavy Chain Is Associated Covalently with an Amino Acid Transporter and Controls Intracellular Trafficking and Membrane Topology of 4F2 Heterodimer*
4F2, also termed CD98, is an integral membrane protein consisting of a heavy chain linked to a light chain by disulfide bond. We have generated a monoclonal antibody to the mouse 4F2 light chain andExpand
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Molecular cloning and structural analysis of mouse gene and pseudogenes for proliferating cell nuclear antigen.
We have isolated clones containing the entire mouse proliferating cell nuclear antigen (PCNA) gene of 3890 bp and flanking sequences using a rat PCNA cDNA as a probe. The mouse gene has 6 exons whoseExpand
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Anomalous regulation of the Drosophila Na(+)-Ca2+ exchanger by Ca2+
The Na(+)-Ca2+ exchanger from Drosophila was expressed in Xenopus and characterized electrophysiologically using the giant excised patch technique. This protein, termed Calx, shares 49% amino acidExpand
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D-type cyclin-binding regions of proliferating cell nuclear antigen.
Proliferating cell nuclear antigen (PCNA) is an auxiliary protein for DNA polymerase delta and is required for both DNA replication and DNA repair. PCNA forms complexes with D-type cyclins, candidateExpand
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Variable product specificity of microsomal dehydrodolichyl diphosphate synthase from rat liver.
Several detergents activated microsomal dehydrodolichyl diphosphate synthase of rat liver, but the chain length of products shifted downward from C90 and C95 with increasing concentration of theExpand
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Molecular Regulation of the Na+‐Ca2+ Exchanger
The use of modern molecular biology to study the Na+-Ca2+ exchanger became possible in 1990 with the cloning of the exchanger of canine cardiac sarcolemma (NCXl).' Subsequently, NCXl and severalExpand
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Differential effect of p53 on the promoters of mouse DNA polymerase beta gene and proliferating-cell-nuclear-antigen gene.
A plasmid carrying the 5' flanking region of the mouse proliferating-cell-nuclear-antigen (PCNA) gene or DNA polymerase beta gene was fused with the chloramphenicol acetyltransferase (CAT) gene, thenExpand
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