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Pharmacological studies on a new antihypertensive agent, S-2150, a benzothiazepine derivative: 2. Hypotensive effects in normotensive and hypertensive rats.
TLDR
The results suggest that S-2150 may be a useful antihypertensive agent possessing both calcium-antagonistic and alpha 1-adrenoceptor-blocking effects. Expand
The pharmacological behavior of the urinary bladder and its vasculature of the dog.
TLDR
Results indicate that the vesical vascular bed has pharmacological characteristics of its own and isoprenaline, adrenaline, dopamine and tyramine caused a relaxation of the bladder and vasoconstriction. Expand
Excitation of the parasympathetic ganglia of the canine urinary bladder through a muscarinic mechanism.
TLDR
The fact that the response to McN A-343 was resistant to blockade by hexamethonium or tetraethylammonium and susceptible instead to blockade in dogs anesthetized with pentobarbital by a small dose of atropine indicates further that excitation of the parasympathetic ganglia of the bladder was mediated through muscarinic rather than nicotinic receptors. Expand
Effect of tetrodotoxin on the bladder response to pelvic nerve stimulation and intra-arterial 1,1-dimethyl-4-phenylpiperazinium and acetylcholine in the dog.
TLDR
From results, it was concluded that the contraction elicited by DMPP was mediated predominantly through excitation of the parasympathetic postganglionic neurons in the bladder wall, while that produced by acetylcholine was exclusively due to excite of the smooth muscle. Expand
The role of alpha-adrenergic receptor mechanism in ejaculation.
TLDR
Both seminal emission and ejaculation are predominantly under the influence of adrenergic nervous system, particularly through an a-adrenergic receptor mechanism. Expand
Antiarrhythmic effect of aprindine on several types of ventricular arrhythmias.
TLDR
Propranolol had a strong antiarrhythmic effect against epinephrine and ouabain arrhythmias, but it did not increase sinus beats in ischemic arrh rhythmias. Expand
Excitation of the parasympathetic ganglia of the canine urinary bladder by a muscarinic ganglionic stimulant, 4-(m-chlorophenyl-carbamoyloxy)-2-butynyltrimethyl-ammonium chloride (McN-A-343).
TLDR
Results indicate that the parasympathetic ganglia in the bladder wall have muscarinic sites distinct from those activated by nicotinic compounds as do sympathetic ganglia elsewhere. Expand
Pharmacological studies on a new dihydrothienopyridine calcium antagonist. 3rd communication: antihypertensive effects of S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2, 3-b]
TLDR
The antihypertensive effects of S-312-d was the most potent and long-lasting compared with the calcium antagonists, nifedipine, nicardipine), nimodipine and nilvadipine; and flunarizine. Expand
[Comparative studies on the hemodynamic effects of dobutamine, dopamine, and isoproterenol in dogs in experimental shock (author's transl)].
TLDR
Cardiovascular effects of dobutamine (DOB), isoproterenol (Iso), and dopamine (DA) were compared in Beagle dogs under experimental shock and alpha stimulation in the venous system as well as beta 1 stimulation apparently contributes to improvement of the deteriorated hemodynamic state, in experimental shock, as induced in dogs. Expand
[Comparative study between dobutamine and other catecholamines in their effects on the cardiac contraction and rhythm (author's transl)].
TLDR
Dobutamine shows good potential for treating acute cardiac insufficiency and cardiogenic shock, as effects on heart rate and blood pressure are weaker, while activity of DOB to induce spontaneous contractions of papillary muscle was weakest. Expand
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