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Indirubin and Indigo Are Potent Aryl Hydrocarbon Receptor Ligands Present in Human Urine*
It is suggested that the endogenous levels and potencies of indirubin and indigo are such that they activate AhR-mediated signaling mechanisms in vivo. Expand
Estrogen and estrogen mimics contamination in water and the role of sewage treatment
The yeast estrogen screen was applied to sewage treatment process waters to identify the presence of estrogenic activity and to investigate the fate and behavior of estrogenic substances throughExpand
Characterization of polycyclic aromatic hydrocarbons (PAHs) in different size fractions in deposited road particles (DRPs) from Lake Biwa area, Japan.
Although the contribution of PAHs to AhR ligand activity presented in the DRP extracts was relatively low (below 10%), it may be best to remove these DRPs before discharge to receiving water environments. Expand
Propionic acid accumulation in anaerobic digestion of carbohydrates: an investigation on the role of hydrogen gas
This paper describes the experimental investigation into the accumulation of propionic acid under artificially lowered or elevated hydrogen gas levels. Vacuum operation at 0.13, 0.5, and 0.75 atm onExpand
Aryl hydrocarbon receptor-mediated induction of microsomal drug-metabolizing enzyme activity by indirubin and indigo.
The results suggest that indirubin and indigo act as inducers for cytochrome P450 1A1/2 mediated by AhR in mammals in vivo. Expand
Aryl hydrocarbon receptor ligand activity of polycyclic aromatic ketones and polycyclic aromatic quinones.
Activation of AhR by 41 polycyclic aromatic compounds (PACs), focusing especially on PAKs and PAQs, was determined by measuring beta-galactosidase activity from a reporter plasmid in yeast engineered to express human AhR and the AhR nuclear translocator proteins and by measuring luciferase activityFrom mouse hepatoma (H1L1) cells (chemical-activatedLuciferase expression [CALUX] assay). Expand
Propionic acid accumulation and controlling factors in anaerobic treatment of carbohydrate: Effects of H2 and pH
Propionic acid is believed to be the most retardative volatile acid appearing in the anaerobic treatment process. However, the mechanisms by which propionic acid accumulates have not been wellExpand
Development of the adductome approach to detect DNA damage in humans.
ADNA adduct detection method that uses liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) to detect multiple DNA adducts in human lung tissue is reported herein. Expand
Specific tandem GG to TT base substitutions induced by acetaldehyde are due to intra-strand crosslinks between adjacent guanine bases.
It is proposed that the DNA damage caused by acetaldehyde is removed by the nucleotide excision repair pathway, and such changes can be used as a probe to identify acetaldehyde as the causal agent in human tumors. Expand
Comparison of gene expression patterns between 2,3,7,8-tetrachlorodibenzo-p-dioxin and a natural arylhydrocarbon receptor ligand, indirubin.
It is suggested that indirubin rapidly activates its own metabolism via AhR-mediated induction of CYP1A1 and this characteristic is consistent with the notion that indIRubin is a physiological ligand of AhR. Expand