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An RGD spacing of 440 nm is sufficient for integrin alpha V beta 3- mediated fibroblast spreading and 140 nm for focal contact and stress fiber formation
It was concluded that a peptide-to-peptide spacing of 440 nm was required for alpha V beta 3-mediated cellular spreading, while 140 nm was needed foralpha V beta3-mediated focal contact formation and normal stress fiber organization in human foreskin fibroblasts; these spacings represent much fewer ligands than were previously thought to be required. Expand
In vitro assessment of bioactive coatings for neural implant applications.
It was concluded that neuron-selective substrates are feasible using dextran-based surface chemistry strategies and could be utilized to establish a stable neural tissue-implant interface for long-term performance of neural prosthetic devices. Expand
Endothelial Cell-Selective Materials for Tissue Engineering in the Vascular Graft Via a New Receptor
This approach may provide a basis for a tissue engineered vascular graft where endothelial cell attachment is desired, but not the attachment of other blood vessel wall cells and blood platelets. Expand
Vascular endothelial cell adhesion and spreading promoted by the peptide REDV of the IIICS region of plasma fibronectin is mediated by integrin alpha 4 beta 1.
It is demonstrated for the first time that alpha 4 is present in the endothelial cell membrane, in contrast to previous reports by others, and that integrin alpha 4 beta 1 is the receptor for REDV-mediated adhesion to the IIICS region of region of plasma fibronectin. Expand
Covalent surface immobilization of Arg-Gly-Asp- and Tyr-Ile-Gly-Ser-Arg-containing peptides to obtain well-defined cell-adhesive substrates.
This derivatization method produced chemically stable substrates which may be useful in studying receptor-mediated cell adhesion, as the quantity of peptide available at the surface may be precisely measured and controlled. Expand
Covalently immobilized laminin peptide Tyr-Ile-Gly-Ser-Arg (YIGSR) supports cell spreading and co-localization of the 67-kilodalton laminin receptor with alpha-actinin and vinculin.
The results suggest that the adhesion ligand YIGSR is solely sufficient for cell spreading when it is conformationally constrained by covalent attachment to a solid substrate, at least when attached via its amino terminus. Expand
Covalently Attached GRGD on Polymer Surfaces Promotes Biospecific Adhesion of Mammalian Cells a
Nearly all mammalian cell adhesion to synthetic polymer surfaces is controlled by adsorbed proteins and is receptor-mediated, and these structurally and functionally related receptor families are known as the integrin superfamily. Expand
Polyimide-based intracortical neural implant with improved structural stiffness
A novel structure for chronically implantable cortical electrodes using polyimide bio-polymer was devised, which provides both flexibility for micro-motion compliance between brain tissues and theExpand
Human endothelial cell interactions with surface-coupled adhesion peptides on a nonadhesive glass substrate and two polymeric biomaterials.
  • S. Massia, J. Hubbell
  • Materials Science, Medicine
  • Journal of biomedical materials research
  • 1 February 1991
Although PET and PTFE-OH supported adhesion when incubated in serum-supplemented medium, neither of these materials support adhesion with only albumin present, indicating that cell adhesion is mediated by adsorbed CAM proteins. Expand
Glial cell and fibroblast cytotoxicity study on plasma-deposited diamond-like carbon coatings.
It can be concluded from these studies that DLC coatings do not adversely affect 3T3 fibroblast and T98-G glial cell function in vitro and that future work will further develop DLC Coatings on prototype microelectrode devices for chronic neural implant applications. Expand