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Quantitative determination of crystallinity of alpha-lactose monohydrate by Near Infrared Spectroscopy (NIRS).
TLDR
NIRS can be used for the quantitative determination of crystallinity of materials during pharmaceutical procedures and showed that NIRS is an useful method for accurately determining low quantities of the crystalline lactose in a physical mixture. Expand
Application of sucrose fatty acid esters in transdermal therapeutic systems.
TLDR
In vitro studies indicated that SEs of shorter fatty acid chain length and higher HLB value increased the amount of released drug about 10 times and could be promising agents in transdermal therapeutic systems to control the drug release and cutaneous absorption. Expand
Effect of the formulation parameters on the characteristics of pellets.
TLDR
Under optimal conditions, particles were prepared for coating in a high-shear mixer, which is used to produce uniform particles, modeled by a second-order polynomial equation fitted to the data gathered by a face-centered central composite statistical design. Expand
A new method for high-performance liquid chromatographic determination of drotaverine in plasma.
TLDR
A sensitive, specific high-performance liquid chromatographic procedure was developed for the determination of plasma drotaverine levels and the utility of this method for determination of drotaVerine in dog and rat plasma was demonstrated. Expand
Influence of chlorhexidine species on the liquid crystalline structure of vehicle.
TLDR
As a result of liquid crystal--drug interaction, the solubility of chlor hexidine base and its diffusion through lipophilic membranes increased in comparison with those of the chlorhexidine salts. Expand
New formulation of in situ gelling Metolose-based liquid suppository
TLDR
According to this study, Metolose® has the physical and chemical potential to be used as base for liquid suppository and was found to be the most appropriate compound. Expand
The effect of liquid crystalline structure on chlorhexidine diacetate release.
TLDR
The results indicate that the drug release kinetic is strongly dependent on the liquid crystalline structure. Expand
In vitro simulation of food effect on dissolution of deramciclane film-coated tablets and correlation with in vivo data in healthy volunteers.
TLDR
In vitro modelling of in vivo conditions might help provide a base for predicting in vivo drug behaviour and establish a linear relationship between logarithmic in vivo blood sampling time and in vitro dissolution time assigned to equal AUC(cum) ratios. Expand
Potential application of Metolose in a thermoresponsive transdermal therapeutic system.
TLDR
The results demonstrated that the effect of different salts (NaCl, NaHCO(3), KCl) of various concentrations in Metolose SH gel reduced T(1) to the skin temperature, which enabled enhanced drug release. Expand
Formulation of thermoresponsive and bioadhesive gel for treatment of oesophageal pain and inflammation.
TLDR
Morphological test of oesophageal tissue showed that investigated materials had no irritative or tissue-damaging effect on the oesophileal mucosa even after 12h, and in vitro adhesion test pointed out that the condition of investigated membrane can change the adhesion. Expand
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