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Ptilomycalin A, crambescidin 800 and related new highly cytotoxic guanidine alkaloids from the starfishes Fromia monilis and Celerina heffernani
Abstract Two novel pentacyclic guanidine alkaloids, celeromycalin 3 and fromiamycalin 4 , have been isolated from the New Caledonian starfishes Celerina heffernani and Fromia monilis , respectively.Expand
Perthamides C-F, potent human antipsoriatic cyclopeptides
Abstract Two new cyclopeptides, perthamides E and F were isolated from the polar extracts of the sponge Theonella swinhoei . The new structures, featuring an unprecedented β-amino acid unit (AHMOA),Expand
Investigation of the polar steroids from an Antarctic Starfish of the family Echinasteridae: isolation of twenty seven polyhydroxysteroids and steroidal oligoglycosides, structures and biological
Abstract An investigation of the extracts from a starfish collected in the Antarctic Sea, Echinasteridae family, has led to the isolation of thirteen glycosides of polyhydroxysteroids (1–13),Expand
Perthamides C and D, two new potent anti-inflammatory cyclopeptides from a Solomon Lithistid sponge Theonella swinhoei
Two new metabolites, perthamides C and D, have been isolated from the marine sponge Theonella swinhoei. Their structures were determined by interpretation of NMR and ESIMS data. All compoundsExpand
Coscinolactams A and B: new nitrogen-containing sesterterpenoids from the marine sponge Coscinoderma mathewsi exerting anti-inflammatory properties.
Abstract Investigation of the marine sponge Coscinoderma mathewsi led to the isolation of two novel nitrogen-containing cheilanthane sesterterpenoids, coscinolactams A and B, together with knownExpand
4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity
It is demonstrated that swinhosterol B counter-regulates induction of pro-inflammatory cytokines in a PXR-dependent manner and pave the way to development of a dual PX R agonist/FXR antagonist with a robust immunomodulatory activity and endowed with the ability to modulate the expression of bile acid-regulated genes in the liver. Expand
Antioxidant activity of phenolic and phenylethanoid glycosides from Teucrium polium L
In the present study, the chemical composition and antioxidant activities of Teucrium polium L. (Lamiaceae) were assessed. Fractionation of methanol extract obtained from the aerial parts of T.Expand
Gracilioethers E–J, new oxygenated polyketides from the marine sponge Plakinastrella mamillaris
Abstract Purification of the apolar extracts of the marine sponge Plakinastrella mamillaris afforded the isolation of six new oxygenated polyketides, gracilioethers E–J, featuring an unprecedentedExpand
A new steroidal alkaloid from a marine sponge Corticium sp
Abstract Two new steroidal alkaloids 3α-amino-23,29-imino-B(9a)-homo-19-nor-5α-stigmasta-1(10),7,9(11),23(N)-tetraene ( 1 ) andExpand