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Artificial skin in perspective: concepts and applications
TLDR
Several types of human skin recombinants, also called artificial skin, that provide this critical 3D structure have now been reconstructed in vitro and this review contemplates the use of these organotypic skin models in different applications, including substitutes to animal testing.
Male infertility: a public health issue caused by sexually transmitted pathogens
TLDR
Chronic or inadequately treated infections seem to be more relevant to infertility than acute infections are, although in many cases the exact aetiological agents remain unknown.
Dual Effect of Serum Amyloid A on the Invasiveness of Glioma Cells
TLDR
Investigation of the effect of human recombinant SAA on two human glioma cell lines suggests that some tumor cells are responsive to SAA and, in these cases, SAA may have a role in cancer progression that varies according to the cell type.
HDAC Inhibition Enhances the In Vivo Efficacy of MEK Inhibitor Therapy in Uveal Melanoma
TLDR
In vivo, the MEK-HDAC inhibitor combination outperformed either agent alone, leading to a long-term decrease of tumor growth in both subcutaneous and liver metastasis models and the suppression of adaptive PI3K/AKT and YAP signaling.
Sensitive Simultaneous Detection of Seven Sexually Transmitted Agents in Semen by Multiplex-PCR and of HPV by Single PCR
TLDR
This M-PCR assay has great potential for application in semen screening programs for pathogens in infertility and STD clinics and in sperm banks and associations were observed between STDs and changes in semen parameters, highlighting the importance of STD detection in semen.
HPV16 Oncoproteins Induce MMPs/RECK-TIMP-2 Imbalance in Primary Keratinocytes: Possible Implications in Cervical Carcinogenesis
TLDR
The results indicate that HPV oncoproteins promote MMPs/RECK-TIMP-2 imbalance which may be involved in HPV-associated lesions outcome and a decrease in RECK expression levels in precancer and cancer lesions.
Oxidative Stress Triggered by Apigenin Induces Apoptosis in a Comprehensive Panel of Human Cervical Cancer-Derived Cell Lines
TLDR
It is demonstrated that apigenin had a selective cytotoxic effect and could induce apoptosis in all cervical cancer cell lines which were positively marked with Annexin V, but not in HaCaT (control cells).
Higher expression and activity of metalloproteinases in human cervical carcinoma cell lines is associated with HPV presence.
TLDR
The results suggest that the presence of HPV is related to increased expression of MMP-2, MT1-MMP, and TIMP- 2, and that pro-M MP-2 activity is higher in HPV-positive than in HPV -negative cells.
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