A Facile, One‐Step Conversion of 6‐O‐Trityl and 6‐O‐TBDMS Monosaccharides into the Corresponding Formate Esters
- D. Komiotis, G. Agelis, S. Manta, Niki Tzioumaki, E. Tsoukala, K. Antonakis
- Chemistry
- 1 August 2006
A convenient method has been developed for a facile and high‐yield conversion of 6‐O‐tert‐butyldimethylsilyl and 6‐O‐trityl protected monosaccharides to their formate esters, which may serve as…
Dissipation, metabolism and sorption of pesticides used in fruit-packaging plants: Towards an optimized depuration of their pesticide-contaminated agro-industrial effluents.
- P. Karas, Aria Metsoviti, D. Karpouzas
- Environmental ScienceScience of the Total Environment
- 15 October 2015
1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies.
- Vicky G Tsirkone, E. Tsoukala, D. Leonidas
- Chemistry, BiologyBioorganic & Medicinal Chemistry
- 15 May 2010
Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation.
- V. Parmenopoulou, D. Chatzileontiadou, D. Leonidas
- Chemistry, BiologyBioorganic & Medicinal Chemistry
- 15 December 2012
A novel and easy two-step, microwave-assisted method for the synthesis of halophenyl pyrrolo[2,3-b]quinoxalines via their pyrrolo precursors. Evaluation of their bioactivity
- S. Manta, Dimitra-Niki Gkaragkouni, Dimitrios Komiotis
- Chemistry
- 12 March 2014
Antioxidant Activity of a Series of Fluorinated Pyrano-nucleoside Analogues of N4-benzoyl Cytosine and N6-benzoyl Adenine
- C. Spanou, S. Manta, Dimitrios Komiotis, A. Dervishi, D. Kouretas
- Chemistry, BiologyInternational Journal of Molecular Sciences
- 1 July 2007
None of the molecules showed the ability to scavenge DPPH radical and prevent OH• induced DNA strand breakage, although, most of the tested nucleoside analogues, had the able to prevent ROO• inducedDNA damage.
Competitive inhibition of human poly(A)-specific ribonuclease (PARN) by synthetic fluoro-pyranosyl nucleosides.
- N. Balatsos, D. Vlachakis, C. Stathopoulos
- Chemistry, BiologyBiochemistry
- 16 June 2009
The results support the idea that the sugar moiety mediates the stabilization of the nucleoside into the active site through interactions with catalytic amino acid residues, and suggest that human PARN is among the molecular targets of these compounds and could act therapeutically by lowering the mRNA turnover rate.
Fluoro-ketopyranosyl nucleosides: synthesis and biological evaluation of 3-fluoro-2-keto-beta-D-glucopyranosyl derivatives of N4-benzoyl cytosine.
- S. Manta, G. Agelis, Tanja Botić, A. Cencič, D. Komiotis
- ChemistryBioorganic & Medicinal Chemistry
- 15 January 2007
Unsaturated fluoro-ketopyranosyl nucleosides: synthesis and biological evaluation of 3-fluoro-4-keto-beta-d-glucopyranosyl derivatives of N(4)-benzoyl cytosine and N(6)-benzoyl adenine.
- S. Manta, G. Agelis, Tanja Botić, A. Cencič, D. Komiotis
- ChemistryEuropean journal of medicinal chemistry
- 1 February 2008
The σ‐Hole Phenomenon of Halogen Atoms Forms the Structural Basis of the Strong Inhibitory Potency of C5 Halogen Substituted Glucopyranosyl Nucleosides towards Glycogen Phosphorylase b
- Anastasia L. Kantsadi, J. Hayes, D. Leonidas
- ChemistryChemMedChem
- 1 April 2012
Ex vivo experiments demonstrated that the most potent derivative toward purified GP has no cytotoxicity and moderate inhibitory potency at the cellular level, and ADMET property predictions were performed, and suggest decreased polar surface areas as a potential means of improving activity in the cell.
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