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Histone acetylation and the cell-cycle in cancer.
A number of distinct surveillance systems are found in mammalian cells that have the capacity to interrupt normal cell-cycle progression. These are referred to as cell cycle check points.Expand
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Cell-cycle dysregulation and the molecular mechanisms of prostate cancer.
Prostate cancer is the most common cause of non-cutaneous cancer in men and although frequently latent is the second commonest cause of death. Screening for the disease was historically based onExpand
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The Cockayne syndrome group B DNA repair protein as an anti-cancer target.
Cells from individuals with Cockayne syndrome (CS) have a defect in transcription-coupled DNA repair (TCR), which rapidly corrects certain DNA lesions located on the transcribed strand of activeExpand
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DNA demethylating agents and epigenetic therapy of cancer.
Epigenetic events have been associated with virtually every step of tumor development and progression, and epigenetic alterations are believed to occur early in tumor development and may precede theExpand
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Role of Circulating Cell-Free DNA in Cancers
Liquid biopsy is a term used to describe non-invasive tests, which provide information about disease conditions through analysis of circulating cell-free DNA and circulating tumor cells fromExpand
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Identification of lncRNAs associated with early stage breast cancer and their prognostic implications
Breast cancer is a common malignancy among women with the highest incidence rate worldwide. Dysregulation of long non-coding RNAs occurring in the preliminary stages of breast carcinogenesis isExpand
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Perspectives of long non-coding RNAs in cancer
A recent advance in transcriptomics has spawned the ‘Decade of non-coding RNAs’ by potentiating the growing numbers of long non-coding RNA in cancer. LncRNA involvement in cancer denotes itsExpand
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Epigenetic silencing of sFRP1 activates the canonical Wnt pathway and contributes to increased cell growth and proliferation in hepatocellular carcinoma
The Wnt pathway is a key regulator of embryonic development and stem cells, and its aberrant activation is associated with human malignancies, most notably hepatocellular carcinoma (HCC). EpigeneticExpand
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DNA methylation changes associated with risk factors in tumors of the upper aerodigestive tract
Cancers of the upper aerodigestive tract (UADT) are common forms of malignancy associated with tobacco and alcohol exposures, although human papillomavirus and nutritional deficiency are alsoExpand
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Identification of lncRNAs associated with early‐stage breast cancer and their prognostic implications
Breast cancer is the most common malignancy among women, with the highest incidence rate worldwide. Dysregulation of long noncoding RNAs during the preliminary stages of breast carcinogenesis isExpand
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