• Publications
  • Influence
Quercetin: Critical Evaluation as an Antileishmanial Agent In Vivo in Hamsters Using Different Vesicular Delivery Modes
Chemotherapy is still a major challenge for in vivo drug targeting to macrophages. Toxicity remains the major obstacle for the most potent drugs already known in the therapy of leishmaniasis. Thus,Expand
  • 40
  • 4
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate.
F344 rats fed diets containing phenethyl isothiocyanate (PEITC, 3 mumol/g diet), a cruciferous vegetable component, before and during treatment with the tobacco-specific carcinogenExpand
  • 196
  • 3
  • PDF
Effect of brain monoamines on the secretion of adrenocorticotrophic hormone.
The role of brain monoamines (5-HT, NA and DA) in the secretion of adrenocorticotrophic hormone (ACTH) was studied in view of contradictory reports. Plasma corticosterone levels and the rate ofExpand
  • 24
  • 3
  • PDF
Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I.
Luteolin, a naturally occurring flavonoid, is abundant in our daily dietary intake. It exhibits a wide spectrum of pharmacological properties, but little is known about its biochemical targets otherExpand
  • 164
  • 1
  • PDF
Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives.
BACKGROUND Betulinic acid, a naturally abundant, plant derived, pentacyclic triterpenoid possesses anti-HIV, anti-malarial and anti-inflammatory properties and has recently emerged as a potentExpand
  • 99
  • 1
Metabolic activation of 6-nitrochrysene in explants of human bronchus and in isolated rat hepatocytes.
It has previously been shown that 6-nitrochrysene can be activated to electrophilic species capable of reacting with DNA through metabolic pathways that form N-hydroxy-6-aminochrysene orExpand
  • 13
  • 1
Analysis of the free amino acid content in pollen of nine Asteraceae species of known allergenic activity.
The study reports the free amino acid composition of the pollen of nine members of the family Asteraceae, i.e. Ageratum conyzoides L., Blumea oxyodonta DC., Eupatorium odoratum L., Gnaphalium indicumExpand
  • 48
  • 1
  • PDF
New Iridoid Glucoside from Picrorhiza kurroa Royle ex Benth.
Picrorhiza kurroa Royle ex Benth, commonly known as kutki is used as a crude drug reported in Indian pharmacopoeia. Acetyl derivative of a new iridoid glucoside, picroside V (6-m-methoxybenzoylExpand
  • 4
  • 1
Therapeutic use of quercetin in the control of infection and anemia associated with visceral leishmaniasis.
Flavonoids are a broad class of plant phenolics that are known to possess a well-established protective effect against membrane lipoperoxidative damages. Oxidative damage of erythrocytes has beenExpand
  • 54
Targeting of Liposomal Flavonoid to Liver in Combating Hepatocellular Oxidative Damage
The efficacy of mannosylated liposome formulations with Quercetin (QC, a flavonoid antioxidant isolated from indigenous origin) has been tested in vivo against carbon tetrachloride(CCl 4) -inducedExpand
  • 28