Second-Generation Antiandrogens: From Discovery to Standard of Care in Castration Resistant Prostate Cancer
A thorough overview of FDA approved second-generation anti-androgen discovery, treatment application, strategies for combination therapy to overcome resistance, and an insight for the potential future approaches for therapeutic inhibition of androgen receptor are provided.
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex
A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo.
Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.
- Vineet Kumar, Sarvesh Kumar, S. Malhotra
- Chemistry, BiologyJournal of Medicinal Chemistry
- 23 June 2011
The studies showed 2-trifluoromethyl-2'-methoxychalone (2b) to be a potent activator of Nrf2, both in vitro and in mice, and showed that the activation of NRF2 by this compound is independent of reactive oxygen species or redox changes.
Study on the potential anti-cancer activity of phosphonium and ammonium-based ionic liquids.
NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation.
- Jung-Hyun Kim, R. Thimmulappa, S. Biswal
- Biology, MedicineJournal of Clinical Investigation
- 3 February 2014
It is determined that activation of nuclear factor erythroid-2-related factor 2 (NRF2) signaling enhances hematopoietic stem progenitor cell (HSPC) function and mitigates IR-induced myelosuppression and mortality in mice.
Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer.
Data reveal that, in addition to recognized roles of Hsp40 and Hsp70 in FL-AR LBD remodeling, ARv lacking the LBD remain dependent on molecular chaperones for stability and function.
Friedel-Crafts acylation reactions in pyridinium based ionic liquids
Modification of cationic nanoclays with ionic liquids