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Androgens in pregnancy: roles in parturition
BACKGROUND Understanding the physiology of pregnancy enables effective management of pregnancy complications that could otherwise be life threatening for both mother and fetus. A functional uterusExpand
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Perimenopausal management of ovarian endometriosis and associated cancer risk: When is medical or surgical treatment indicated?
In women with endometriosis, the lifetime risk of ovarian cancer is increased from 1.4% to about 1.9%. The risk of clear cell and endometrioid ovarian cancer is, respectively, tripled and doubled.Expand
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Human Cathelicidin Production by the Cervix
hCAP18/LL-37 is the sole human cathelicidin; a family of host defence peptides with key roles in innate host defence. hCAP18/LL-37 is expressed primarily by neutrophils and epithelial cells, but itsExpand
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Androgen-Induced Relaxation of Uterine Myocytes Is Mediated by Blockade of Both Ca(2+) Flux and MLC Phosphorylation.
CONTEXT Uterine quiescence must be maintained until pregnancy reaches term. Premature activation of myometrial contractility leads to preterm labor and delivery. OBJECTIVE To scrutinize theExpand
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The preterm cervix reveals a transcriptomic signature in the presence of premature prelabor rupture of membranes
BACKGROUND: Premature prelabor rupture of fetal membranes accounts for 30% of all premature births and is associated with detrimental long‐term infant outcomes. Premature cervical remodeling,Expand
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Abnormal sperm concentration and motility as well as advanced paternal age compromise early embryonic development but not pregnancy outcomes: a retrospective study of 1266 ICSI cycles
PurposeTo investigate the effect of sperm concentration, motility and advanced paternal age on reproductive outcomes.MethodsA retrospective analysis of 1266 intracytoplasmic sperm injection (ICSI)Expand
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Endometriosis: seeking optimal management in women approaching menopause
Abstract The incidence of endometriosis in middle-aged women is not minimal compared to that in the reproductive age group. The treatment of affected women after childbearing age to the naturalExpand
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Immune cell and transcriptomic analysis of the human decidua in term and preterm parturition
Abstract STUDY QUESTION Is labour, both at term and preterm, associated with alterations in decidual lymphocyte densities and widespread changes to the decidual transcriptome? SUMMARY ANSWER TheExpand
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Ultrasound-guided intrauterine injection of lipopolysaccharide as a novel model of preterm birth in the mouse.
Mouse models are used to study mechanisms that link intrauterine infection and preterm birth (PTB). To mimic intrauterine infection, lipopolysaccharide (LPS) is commonly injected into the uterus viaExpand
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Expression of Matrix Metalloproteinases in the Mouse Uterus and Human Myometrium During Pregnancy, Labor, and Preterm Labor
Background: Uterine extracellular matrix (ECM) remodeling occurs throughout pregnancy and at parturition. Imbalanced availability of key mediators in ECM degradation, namely, matrixExpand
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