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The Concentrations of Calcium Buffering Proteins in Mammalian Cochlear Hair Cells
TLDR
Ca2+ is used in inner hair cells primarily for fast phase-locked synaptic transmission, whereas Ca2+ may be involved in regulating the motor capability underlying cochlear amplification of the outer hair cell.
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The role of transmembrane channel–like proteins in the operation of hair cell mechanotransducer channels
TLDR
It is concluded that the Tmc isoforms do not themselves constitute the MT channel but are essential for targeting and interaction with the tip link and changes in the MT conductance and Ca2+ permeability observed in the absence of Tmc1 mutants may stem from loss of interaction with protein partners in the transduction complex.
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The Dimensions and Composition of Stereociliary Rootlets in Mammalian Cochlear Hair Cells: Comparison between High- and Low-Frequency Cells and Evidence for a Connection to the Lateral Membrane
TLDR
The structure and dimensions of rootlets relative to the stereocilia in apical and basal regions of rodent cochleae using light and electron microscopy suggest that rootlets strengthen the ankle region to provide durability and may contact with the lateral wall either to give additional anchoring of the stereOCilia or to provide a route for interactions between the bundle and theateral wall.
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The ultrastructural distribution of prestin in outer hair cells: a post‐embedding immunogold investigation of low‐frequency and high‐frequency regions of the rat cochlea
TLDR
The results suggest that prestin density, and by implication force production, is similar in low‐frequency and high‐frequency OHCs.
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Differential distribution of β- and γ-actin in guinea-pig cochlear sensory and supporting cells
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The development, distribution and density of the plasma membrane calcium ATPase 2 calcium pump in rat cochlear hair cells
TLDR
The limited ability of PMCA2 to extrude the Ca2+ load through MT channels may constitute a major cause of OHC vulnerability and high‐frequency hearing loss.
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Spermatogenesis and the fine structure of the mature spermatozoon in the free proglottis ofTrilocularia acanthiaevulgaris (Cestoda, Tetraphyllidea)
TLDR
Spermatogenesis and the structure of the mature spermatozoon of Trilocularia acanthiaevulgaris have been studied by light microscopic histochemistry and transmission and scanning electron microscopy and are placed in context within the phylogenetic schemes for cestodes based on sperm ultrastructure.
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Differential distribution of beta- and gamma-actin in guinea-pig cochlear sensory and supporting cells.
TLDR
Post-embedding immunogold labelling for beta- and gamma-actin is used to confirm differential distribution of these actin isoforms in the mammalian cochlea and reveal systematic differences between sensory and supporting cells.
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The Distribution of Calcium Buffering Proteins in the Turtle Cochlea
TLDR
It is suggested that calbindin-D28k and parvalbumin-β may serve as endogenous mobile calcium buffers, but the predominantly nuclear location of calretinin argues for another role in calcium signaling.
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Two approaches to double post-embedding immunogold labeling of freeze-substituted tissue embedded in low temperature Lowicryl HM20 resin.
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