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Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases.
The molecular mechanisms by which tumor cells metastasize to bone are likely to involve invasion, cell adhesion to bone, and the release of soluble mediators from tumor cells that stimulateExpand
Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices.
The molecular mechanisms by which tumor cells induce osteolytic metastases are likely to involve tumor cell adhesion to bone as well as the release of soluble mediators from tumor cells thatExpand
Additive antitumor activities of taxoids in combination with the bisphosphonate ibandronate against invasion and adhesion of human breast carcinoma cells to bone
A very common metastatic site for breast carcinoma is bone. Metastatic breast carcinoma cells stimulate osteoclast‐mediated bone resorption leading to osteolysis. Bisphosphonates are powerfulExpand
CD36 mediates binding of soluble thrombospondin‐1 but not cell adhesion and haptotaxis on immobilized thrombospondin‐1
In this study, we examined the binding of soluble TSP1 (and ox‐LDL) to CD36‐transfected cells and the mechanisms by which immobilized TSP1 mediated attachment and haptotaxis (cell migration towards aExpand
[Thrombospondins, tumor angiogenesis and breast cancer].
Thrombospondin-1 and -2 are extracellular matrix proteins that are overexpressed in breast cancer tissue. Their role in breast cancer remains unknown. This article reviews the potential effects ofExpand