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Functional Evaluation of Complete Sciatic, Peroneal, and Posterior Tibial Nerve Lesions in the Rat
Quantification of peripheral nerve regeneration in animal studies of nerve injury and repair by histologic, morphologic, and electrophysiologic parameters has been controversial because such studiesExpand
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Clinical Nerve Reconstruction with a Bioabsorbable Polyglycolic Acid Tube
Microneurosurgical techniques to reconstruct nerve gaps with nerve grafts frequently fail to achieve excellent functional results and create donor-site morbidity. In the present study, 15 patientsExpand
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Nerve Crush Injuries—A Model for Axonotmesis
Nerve crush is a commonly used experimental model in the rat; however, a standard method of inducing this injury has not been defined. This study examined six crush techniques that are frequentlyExpand
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Biomedical engineering strategies for peripheral nerve repair: surgical applications, state of the art, and future challenges.
Damage to the peripheral nervous system is surprisingly common and occurs primarily from trauma or a complication of surgery. Although recovery of nerve function occurs in many mild injuries,Expand
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Surgery of the Peripheral Nerve
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Myelinated afferents signal the hyperalgesia associated with nerve injury
&NA; Pain to light touching of the skin is a hallmark sign of causalgia. The purpose of this study was to determine whether myelinated or unmyelinated afferent fibers signal this hyperalgesia.Expand
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Management of nerve gaps: Autografts, allografts, nerve transfers, and end-to-side neurorrhaphy
Since its introduction in the late 1870’s, surgical restoration of function following peripheral nerve injury has made significant progress (Naff and Ecklund, 2001). The development of the operatingExpand
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Processed allografts and type I collagen conduits for repair of peripheral nerve gaps
Autografting is the gold standard in the repair of peripheral nerve injuries that are not amenable to end‐to‐end coaptation. However, because autografts result in donor‐site defects and are a limitedExpand
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Affinity-based release of glial-derived neurotrophic factor from fibrin matrices enhances sciatic nerve regeneration.
Glial-derived neurotrophic factor (GDNF) promotes both sensory and motor neuron survival. The delivery of GDNF to the peripheral nervous system has been shown to enhance regeneration followingExpand
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Choosing the correct functional assay: A comprehensive assessment of functional tests in the rat
While there are several ways to quantify peripheral nerve regeneration; the true measure of successful outcome is functional recovery. Functional tests are relatively easily conducted in humanExpand
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