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Functional Evaluation of Complete Sciatic, Peroneal, and Posterior Tibial Nerve Lesions in the Rat
TLDR
It was shown that animals with selective nerve injuries gave walking tracks that were consistent, predictable, and based on known neuromuscular deficits, and the new formula for sciatic functional index was compared with previously described indices.
Clinical Nerve Reconstruction with a Bioabsorbable Polyglycolic Acid Tube
TLDR
It is concluded that reconstruction of nerve gaps of up to 3.0 cm with a bioabsorbable PGA tube gives clinical results at least comparable to the classic nerve graft technique while avoiding donor-site morbidity.
Biomedical engineering strategies for peripheral nerve repair: surgical applications, state of the art, and future challenges.
TLDR
The most pressing challenges in peripheral nerve repair include the development of tissue-engineered nerve grafts that match or exceed the performance of autografts, the ability to noninvasively assess nerve damage and track axonal regeneration, and approaches to maintain the efficacy of the distal pathway and targets during the regenerative process.
Myelinated afferents signal the hyperalgesia associated with nerve injury
TLDR
3 lines of evidence indicate that myelinated primary afferents, perhaps A&bgr; fibers, signal the hyperalgesic pain in causalgia, which may be sensitized A&Bgr; nociceptors or low‐threshold mechanoreceptors.
Nerve Crush Injuries—A Model for Axonotmesis
TLDR
Nerve crush, induced by any of the six methods tested, was similar and provides a reliable model of axonotmesis.
Management of nerve gaps: Autografts, allografts, nerve transfers, and end-to-side neurorrhaphy
TLDR
This review summarizes these options for repair including interpositional nerve grafting, transfers and end-to-side neurorrhaphy, which leads to improved outcomes by allowing for earlier distal motor end plate and sensory receptor reinnervation.
Walking Track Analysis: A Long‐Term Assessment of Peripheral Nerve Recovery
TLDR
Assessment of neural regeneration using walking track analysis appears to be a valuable addition to the traditional methods of histology and electrophysiology, reaching near-optimal recovery by 12 weeks.
Processed allografts and type I collagen conduits for repair of peripheral nerve gaps
TLDR
It is concluded that, particularly in a long gap model, nerve graft alternatives fail to confer the regenerative advantages of an isograft, but AxoGen processed allografts are superior to a currently available conduit‐style nerve guide, the Integra NeuraGen®.
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