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Identification and evaluation of the microbiome in the female and male reproductive tracts
- R. Koedooder, S. Mackens, +4 authors S. Schoenmakers
- Biology, Medicine
- Human reproduction update
- 1 May 2019
An overview of the currently used techniques and the reported microbiota compositions in the different anatomical parts of the female and male reproductive tracts since the introduction of NGS in 2005 is provided to understand and determine the interactions and roles of the different microbes necessary for successful reproduction. Expand
Frozen embryo transfer: a review on the optimal endometrial preparation and timing
A standardized timing strategy based on the current available evidence which could assist in the harmonization and comparability of clinic practice and future trials is proposed, with special attention to the timing of the embryo transfer. Expand
The effect of an immediate frozen embryo transfer following a freeze-all protocol: a retrospective analysis from two centres.
- S. Santos-Ribeiro, N. Polyzos, +5 authors C. Blockeel
- Biology, Medicine
- Human reproduction
- 21 November 2016
This study offers a simple but potentially relevant measure to increase patient satisfaction and adherence in couples who seek to become pregnant both safely and as soon as possible and the results are limited by the retrospective design and the potential for unmeasured confounding. Expand
Frozen-thawed embryo transfers in natural cycles with spontaneous or induced ovulation: the search for the best protocol continues.
The use of mNC-FET, using hCG triggering or progesterone supplementation, should be reconsidered in light of the potential negative effect on pregnancy outcome. Expand
Expression of adhesion and extracellular matrix genes in human blastocysts upon attachment in a 2D co-culture system
- A. Aberkane, W. Essahib, +7 authors H. Van de Velde
- Biology, Medicine
- Molecular human reproduction
- 1 July 2018
A 'proof of concept' that initiation of the implantation process coincides with the induction of specific embryonic genes is provided, and genome-wide expression profiling of a larger sample set may provide insights into the molecular embryonic pathways underlying successful or failed implantation. Expand
Impact of late-follicular phase elevated serum progesterone on cumulative live birth rates: is there a deleterious effect on embryo quality?
The results raise the question whether EP may also be associated with a decrease in cumulative pregnancy outcomes by increasing embryo wastage, and the potential benefit of additional measures besides the freeze-all strategy to avoid this issue. Expand
Hereditary breast and ovarian cancer and reproduction: an observational study on the suitability of preimplantation genetic diagnosis for both asymptomatic carriers and breast cancer survivors
- I. Derks-Smeets, C. Die-Smulders, +12 authors W. Verpoest
- Breast Cancer Research and Treatment
- 19 April 2014
PGD for HBOC proved to be suitable, yielding good pregnancy rates for asymptomatic carriers as well as breast cancer survivors, and maternal safety of IVF(PGD) in female carriers needs further evaluation. Expand
A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF.
Despite 50% of patients dropping out compared with 30% initially planned, per protocol analysis demonstrates statistically significant improvement in pregnancy, implantation and cumulative live birth rates in PET compared with FET and fresh embryo transfer arms, indicating the potential utility of PET guided by the ERA test at the first appointment. Expand
Towards complication-free assisted reproduction technology.
- S. Santos-Ribeiro, S. Mackens, A. Racca, C. Blockeel
- Best practice & research. Clinical endocrinology…
- 1 February 2019
The rationale and evolution of ovarian stimulation strategies over the years and the current developments towards finding a balance between the retrieval of a sufficient number of oocytes and ART-related complication prevention are discussed. Expand
The freeze-all strategy versus agonist triggering with low-dose hCG for luteal phase support in IVF/ICSI for high responders: a randomized controlled trial.
This study offers the first comparative analysis of two common strategies applied to women performing IVF/ICSI with a high risk to develop OHSS, and suggests a fresh embryo transfer with intensified luteal phase support may still not avoid the risk of moderate-to-severe ovarian hyperstimulation syndrome. Expand