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Inhibition of p21‐mediated ROS accumulation can rescue p21‐induced senescence
The cyclin‐dependent kinase (CDK) inhibitor p21Waf1/Cip1/Sdi1 was identified initially as a gene induced in senescent cells and itself has been shown to cause permanent growth arrest/senescence.Expand
Influence of Induced Reactive Oxygen Species in p53-Mediated Cell Fate Decisions
It is implied that therapeutic agents that generate ROS are more likely to be toxic for normal cells than p53-negative tumor cells and provide a rationale for identifying therapeuticagents that do not complement p53 in ROS generation to ameliorate the cytotoxic side effects in normal cells. Expand
ASC is a Bax adaptor and regulates the p53–Bax mitochondrial apoptosis pathway
Evidence is presented that ASC can function as an adaptor molecule for Bax and regulate a p53–Bax mitochondrial pathway of apoptosis and induction of ASC after exposure to genotoxic stress is dependent on p53. Expand
Transcriptional role of p53 in interferon-mediated antiviral immunity
The results demonstrate that p53 contributes to innate immunity by enhancing IFN-dependent antiviral activity independent of its functions as a proapoptotic and tumor suppressor gene. Expand
Characterization of novel markers of senescence and their prognostic potential in cancer
The results could facilitate the study of senescence, define potential new effectors and modulators of this cellular mechanism and provide potential diagnostic and prognostic tools to be used clinically. Expand
HB-EGF Is a Potent Inducer of Tumor Growth and Angiogenesis
Findings establish s-HB-EGF as a potent inducer of tumor growth and angiogenesis and suggest that therapeutic intervention aimed at the inhibition of s- HB- EGF functions may be useful in cancer treatment. Expand
Characterization of human metapneumovirus infection of myeloid dendritic cells.
Results indicate that hMPV does not induce effective DC maturation in vitro and suggest that the weak stimulation of DCs may account for the overall low immunogenicity of this virus observed in vivo. Expand
Specific interactions of BCL-2 family proteins mediate sensitivity to BH3-mimetics in diffuse large B-cell lymphoma
This study indicates that in DLBCL, the heterogeneous response to BH3-mimetics is mediated by selective interactions between BAX, BAK and anti-apoptotic BCL-2 proteins. Expand
Loss of polycystin-1 causes centrosome amplification and genomic instability.
In vivo evidence that significant centrosome amplification occurs in kidneys from conditional Pkd1 knockout mice at early and late time during the disease progression as well as in human AD PKD patients is provided, establishing a novel function of PC1 in ADPKD pathogenesis. Expand
Stable Knockdown of Polycystin-1 Confers Integrin-α2β1–Mediated Anoikis Resistance
Findings indicate that reduction of PC1 expression levels, rather than the loss of heterozygosity, may be sufficient to induce cystogenesis, and link integrin-α2β1 to some of the biologic functions that are ascribed to PC1. Expand