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In Vitro Anticancer Activity and in Vivo Biodistribution of Rhenium(I) Tricarbonyl Aqua Complexes.
TLDR
The mechanism of action of the most potent complex, 13, was explored further and indicated that 13 induces cytoplasmic vacuolization that is lysosomal in nature, suggesting that a novel mode of action may be operative for this class of rhenium compounds.
Photoactivated in Vitro Anticancer Activity of Rhenium(I) Tricarbonyl Complexes Bearing Water-Soluble Phosphines.
TLDR
Data indicate that the phototoxic response may result from the release of both CO and the rhenium-containing photoproduct, as well as the production of 1O2.
Diastereo- and Enantioselective Formal [3 + 2] Cycloaddition of Cyclopropyl Ketones and Alkenes via Ti-Catalyzed Radical Redox Relay.
TLDR
A stereoselective formal [3 + 2] cycloaddition of cyclopropyl ketones and radical-acceptor alkenes to form polysubstituted cyclopentane derivatives with generally excellent diastereo- and enantioselectivity is reported.
Electronic Structural Analysis of Copper(II)-TEMPO/ABNO Complexes Provides Evidence for Copper(I)-Oxoammonium Character.
TLDR
The emergent electronic structure picture reveals that Cu coordination confers appreciable oxoammonium character to the aminoxyl ligand and has important implications for the mechanism of alcohol oxidation and the underlying basis for cooperativity in this co-catalyst system.
Bis(thiosemicarbazone) Complexes of Cobalt(III). Synthesis, Characterization, and Anticancer Potential.
TLDR
The results provide a structure-activity relationship for this class of compounds, which may be applied for the rational design of new cobalt(III) anticancer agents.
Highly conductive and chemically stable alkaline anion exchange membranes via ROMP of trans-cyclooctene derivatives
TLDR
This work synthesized AAEMs consisting of polyethylene backbones and alkaline-stable imidazolium cations via the living ring-opening metathesis polymerization of trans-cyclooctene monomers, wherein either block or random copolymer sequences can be achieved.
An Eighteen-Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy.
TLDR
Findings establish macropa to be a highly promising ligand for 225 Ac chelation that will facilitate the clinical development of 225 Ac TAT for the treatment of soft-tissue metastases.
Radical Redox-Relay Catalysis: Formal [3+2] Cycloaddition of N-Acylaziridines and Alkenes.
We report Ti-catalyzed radical formal [3+2] cycloadditions of N-acylaziridines and alkenes. This method provides an efficient approach to the synthesis of pyrrolidines, structural units prevalent in
Rh2(II,III) Catalysts with Chelating Carboxylate and Carboxamidate Supports: Electronic Structure and Nitrene Transfer Reactivity.
TLDR
Joint theoretical and experimental studies of the ground electronic state (GES), redox potentials, and C-H amination of Rh2-nitrene intermediates show a KIE ∼ 3 for both 2N and 3N, which is consistent with a concerted mechanism.
Rapid Dissolution of BaSO4 by Macropa, an 18-Membered Macrocycle with High Affinity for Ba2.
TLDR
It is demonstrated that macropa is a highly effective chelator for Ba2+ that can be applied for the remediation of BaSO4 scale and outperforms DTPA and DOTA.
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