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Venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukaemia: a phase 1b study.
BACKGROUND Selective BCL2 inhibition with venetoclax has substantial activity in patients with relapsed or refractory chronic lymphocytic leukaemia. Combination therapy with rituximab enhancedExpand
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Coordinated Redistribution of Leukocyte LFA-1 and Endothelial Cell ICAM-1 Accompany Neutrophil Transmigration
The leukocyte integrin lymphocyte function-associated antigen 1 (LFA-1) and its endothelial ligand intercellular adhesion molecule (ICAM)-1 play an important role in transmigration as demonstrated byExpand
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Cytoplasmic dynein-associated structures move bidirectionally in vivo.
Intracellular organelle transport is driven by motors that act upon microtubules or microfilaments. The microtubulebased motors, cytoplasmic dynein and kinesin, are believed to be responsible forExpand
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Dynein Intermediate Chain Mediated Dynein–Dynactin Interaction Is Required for Interphase Microtubule Organization and Centrosome Replication and Separation inDictyostelium
Cytoplasmic dynein intermediate chain (IC) mediates dynein–dynactin interaction in vitro (Karki, S., and E.L. Holzbaur. 1995. J. Biol. Chem. 270:28806–28811; Vaughan, K.T., and R.B. Vallee. 1995. J.Expand
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Nuclear overexpression of lymphoid-enhancer-binding factor 1 identifies chronic lymphocytic leukemia/small lymphocytic lymphoma in small B-cell lymphomas
Lymphoid-enhancer-binding factor 1 (LEF1), coupling with β-catenin, functions as a key nuclear mediator of WNT/β-catenin signaling, which regulates cell proliferation and survival. LEF1 has anExpand
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Regulation of Leukocyte Transmigration: Cell Surface Interactions and Signaling Events 1
A fundamental event in the inflammatory response is recruitment of blood leukocytes to a site of injury or infection, often resulting in tissue dysfunction and damage. The steps in this recruitmentExpand
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Leukocyte transendothelial migration: a junctional affair.
A critical function of the inflammatory response is delivery of leukocytes to a site of injury, immune reaction or infection. Considerable information is available concerning the molecular mechanismsExpand
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Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia.
Waldenström macroglobulinemia (WM) is characterized by monoclonal gammopathy, usually IgM, in association with lymphoplasmacytic lymphoma (LPL). Little is known of the expression of nuclear proteinsExpand
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Phase II study of alemtuzumab–rituximab therapy in previously untreated patients with chronic lymphocytic leukemia: short- and long-term outcomes
Abstract We investigated the safety, efficacy, and long-term outcomes of alemtuzumab and rituximab (AR) combination therapy in previously untreated patients with CLL. Thirty patients, ages 28–80Expand
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PD‐1 is highly expressed by neoplastic B‐cells in Richter transformation
Hayes, J.D., Flanagan, J.U. & Jowsey, I.R. (2005) Glutathione transferases. Annual Review of Pharmacology and Toxicology, 45, 51–88. Korkolopoulou, P., Thymara, I., Kavantzas, N., Vassilakopoulos,Expand
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