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Comparison of Long-term Antihyperglycemic and Hypolipidemic Effects Between Coccinia cordifolia (Linn.) And Catharanthus roseus (Linn.) In Alloxan-induced Diabetic Rats
TLDR
C. cordifolia was found to be better than C. roseus in lowering blood glucose and serum triglycerides but has lower activity for lowering serum cholesterol on lo ng-term treatment basis in A IDRs. Expand
A KALA-modified lipid nanoparticle containing CpG-free plasmid DNA as a potential DNA vaccine carrier for antigen presentation and as an immune-stimulative adjuvant
TLDR
The robust induction of antigen-specific cytotoxic T-lymphoma activity and the resulting prophylactic and therapeutic anti-tumor effect was observed in mice that had been immunized with bone marrow-derived dendritic cells ex vivo transfected with antigen-encoding pDNA. Expand
Preparation of theophylline hydrogels of atactic poly(vinyl alcohol)/NaCl/H2O system for drug delivery system.
TLDR
A DSC thermogram revealed that apparently homogeneous microgel junctions might play the key role behind the above properties and the a-PVA/TH/NaCl/H2O system depresses the freezing point at -30 degrees C instead of above this temperature. Expand
Quantitative analysis of condensation/decondensation status of pDNA in the nuclear sub-domains by QD-FRET
TLDR
Modulation of the supra-molecular structure of polyrotaxane (DMAE-ss-PRX), a condenser that is cleaved in a reductive environment, conferred euchromatin-preferred decondensation, marking the first demonstration of the successful control of condensation/decondensation in specific nuclear sub-domain via the use of an artificial DNA condenser. Expand
Green Tea in Health Care: A Natural Medicine, A Natural Drink
TLDR
This review gives an impact for having such green teas in every day life because of their role in minimizing many physiological disorders like atherosclerosis, hypertension, diabetes mellitus, obesity and even cancer. Expand
Accelerated Stability Study of Metronidazole Infusion 100 ml
TLDR
Metronidazole infusion had been prepared and studied under acceleration by heat at 37 and 50 °C temperatures and stability data were analyzed by statistical regression analysis and plotted against time, which indicated its lower estimate value. Expand
KALA-modified multi-layered nanoparticles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine.
TLDR
The R8/KALA-T-MEND has the potential for use as a vector in DNA vaccinations by improving the membrane-fusion processes with endosome- and nuclear membranes by incorporating the KALA peptide, and by reducing the charge ratio in an attempt to accelerate intra-nuclear decondensation. Expand
A DNA microarray-based analysis of immune-stimulatory and transcriptional responses of dendritic cells to KALA-modified nanoparticles.
TLDR
The density-dependent enhancement of transgene expression by the simple modification by stearyl-conjugated KALA, an α-helical peptide, onto a lipid envelope-type nanoparticle (the R8-MEND) mounts a "switch-on" function that triggers signal transduction forward to the immune-stimulation analogous to an adjuvant, and consequently elicits active transcription. Expand
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